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This section provides an overview for l-leucine as well as their applications and principles. Also, please take a look at the list of 9 l-leucine manufacturers and their company rankings. Here are the top-ranked l-leucine companies as of December, 2024: 1.Parchem, 2.Yichang Sanxia Proudin Biopharmaceutical Co., Ltd., 3.PerkinElmer Inc..
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Okayama University Graduate School, Ph.D. (Agriculture). After working as a specially appointed Assistant Professor at Tokyo Medical and Dental University, a fluid researcher at the Okayama Prefectural Institute of Biological Sciences, and a special researcher (JSPS PD) at the Japan Society for the Promotion of Japan Science, he became independent as a freelancer.
Specializes in natural product chemistry, protein engineering, fermentation engineering, and instrumental analysis of chemicals (especially mass spectrometry chemistry).
Thesis: https://pubmed.ncbi.nlm.nih.gov/?term=HIROKAZU+USUKI
linkedin: https://www.linkedin.com/in/%E5%8D%9A%E4%B8%80-%E8%87%BC%E6%9C%A8-b83827228/
L-leucine, a branched-chain amino acid (BCAA) along with valine and isoleucine, is one of the 20 amino acids that constitute proteins. It has an isobutyl group on its side chain, making it highly hydrophobic. L-leucine, which exists in L- and D-forms, is found in proteins as the L-isomer.
As an essential amino acid, humans cannot synthesize L-leucine; it must be acquired through diet.
English name: L-leucine
IUPAC name: (2S)-2-amino-4-methylpentanoic acid
3-letter abbreviation: Leu
1-letter abbreviation: L
C6H13NO2
131.17
293-295°C (decomposition)
Slightly soluble in water, insoluble in ethanol.
Slightly bitter
As a BCAA, L-leucine plays a crucial role in muscle fiber proteins. It activates enzymes needed for protein synthesis and induces muscle protein synthesis. Consequently, L-leucine and other BCAAs are popular supplements for strength training. Additionally, L-leucine is known to improve liver function, relieve stress, enhance glucose tolerance and insulin sensitivity, and promote hair growth. It is used in pharmaceuticals for amino acid supplementation and as a food additive.
L-leucine is abundant in various foods, making deficiency rare. However, insufficient intake may impair liver function and reduce insulin secretion. Excessive intake can disrupt the balance with other amino acids, potentially weakening the immune system.
Sources of L-leucine include liver, tuna, mackerel, chicken, dairy products, soy products, eggs, and yogurt.
*Including some distributors, etc.
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PerkinElmer Inc., founded in 1937, is an American manufacturer headquartered in Waltham, Massachusetts, specializing in laboratory technology and management. The company's product offerings include analysis and characterization instruments, software, and consumables. Such offerings cover chromatography, mass spectrometry, molecular and atomic spectroscopy. They also provide immunoassay and food quality analyzers, as well as the simultaneous thermal analyzer (STA). These products find applications in various industries, such as biopharmaceuticals, food safety, lithium battery, and water resource management. PerkinElmer also offers OneSource Laboratory Services, providing knowledge, application, and service solutions for scientific laboratories. Additionally, their LABStartUp program supports new laboratories with instrumentation, consumables, and funding.
Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
Wego Chemical Group was founded in 1978 and headquartered in Great Neck, New York. WEGO is a full-service supplier and distributor of chemicals, minerals, and other raw materials to clients around the world. Markets and segments include agriculture & animal care, chemical & material manufacturing, construction & building materials, electronics, food & beverage, “household, industrial & institutional”, mining, oil & gas, personal care & pharmaceutical, paper & packaging, surface treatment, textiles, and water treatment.
Kyowa Hakko Bio Co., Ltd. was established in 2008 and is based in Tokyo, Japan, as a manufacturer of pharmaceutical raw materials and ingredients. It specializes in manufacturing bulk pharmaceuticals like citicoline, L-glutathione, and L-ornithine aspartate. It also manufactures raw materials for infusions, dietary supplements, and cosmetics, such as amino acids, peptides, oligosaccharides, and nucleic acids. The company is a subsidiary of Kirin Holdings Company and has obtained ISO 22000:2018, ISO/TS 22002-1:2009, and FSSC 22000 certifications. Its manufactured products are utilized in pharmaceuticals, nutritional supplements, industrial, and cosmetics sectors across Japan, China, the USA, Germany, and Italy.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Yichang Sanxia Proudin Biopharmaceutical Co., Ltd., founded in China in 1974, is a manufacturer of Amino Acid series raw materials. The company's product portfolio includes Pharmaceutical Grade Amino Acids, Amino Acids for Special Medical Food, Amino Acids for Medium, High-Purity Pharmaceutical Intermediate Amino Acid and Food Grade Amino Acids. Their products are used in industries such as Food and Beverage, Pharmaceutical and Biotechnology, Chemical and Petrochemical, Environmental Testing and healthcare.
Watanabe Chemical, established in 1951 and headquartered in Osaka, Japan, operates as a manufacturer and supplier of specialty chemicals and advanced materials. The company offers a diverse range of products including fluorinated chemicals, polyurethane additives, functional monomers, specialty resins, and surface modifiers. These products cater to various industries such as electronics, coatings, adhesives, and pharmaceuticals. It holds ISO 9001 certification, showcasing its adherence to quality management systems. The company also has its dark room lab with UV protection lamp to manufacture light-sensitive compounds.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Parchem |
26.3%
|
| 2 | Yichang Sanxia Proudin Biopharmaceutical Co., Ltd. |
15.8%
|
| 3 | PerkinElmer Inc. |
15.8%
|
| 4 | KYOWA HAKKO BIO CO.,LTD. |
15.8%
|
| 5 | nacalai |
15.8%
|
| 6 | Wego Chemical Group Inc |
5.3%
|
| 7 | Tokyo Chemical Industry Co., Ltd. |
5.3%
|
Derivation Method
The ranking is calculated based on the click share within the l-leucine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
4 | 50.0% |
|
United States of America
|
3 | 37.5% |
|
China
|
1 | 12.5% |
