This section provides an overview for iodoform as well as their applications and principles. Also, please take a look at the list of 13 iodoform manufacturers and their company rankings. Here are the top-ranked iodoform companies as of November, 2024: 1.Infinium Pharmachem Pvt. Ltd., 2.Parchem, 3.KANTO CHEMICAL CO.,INC..
Table of Contents
Iodoform is a type of iodine-containing compound called trihalomethane.
Chloroform, a well-known anesthetic, is also a type of trihalomethane and is also called "triiodomethane." It exists as a solid at room temperature, in the form of shiny yellow crystals or powder.
It is almost insoluble in water, but is soluble in organic solvents such as diethyl ether and insoluble in ethanol. It is also slightly volatile at room temperature.
The chemical formula and molecular weight of iodoform are as follows:
Iodoform is used as a disinfectant for wounds and ulcers and as an antiseptic for dental root canals, taking advantage of its high disinfectant effect. Specifically, it is often used in the form of gauze coated with iodoform or blended with eugenol cement to fill deciduous teeth.
The disinfectant effect of iodoform is said to be stronger than ethanol and only weaker than sodium hypochlorite. When using it, care should be taken to avoid getting iodoform powder or dissolved solution in the eyes. In addition, soap can weaken the effect of iodoform, so it is necessary to rinse off the soap before use.
However, iodoform has a specific odor, and disinfectants with stronger effects have been created. As a result, the distribution of iodoform is gradually decreasing and other chemicals are being used. However, iodoform has three iodine atoms and is extremely reactive, and because of its reactivity, it is sometimes used as a reagent in the field of organic chemistry.
Because it contains only one carbon atom, it is often used as an electrophile in methylating agents. Today, opportunities to use it as a reagent are more common than its use as a chemical.
Iodoform gradually liberates iodine in the blood. Since the liberated iodine has an oxidizing effect, it can exert a strong disinfectant effect on tetanus bacteria and tuberculosis bacteria, which secrete a reducing substance.
However, when iodine levels in the blood become high, there is a risk that iodine will bind to proteins in the body and cause neurological poisoning symptoms such as delirium, sleep disorders, memory impairment, and depression. Therefore, it is important to observe the dosage and administration when using this product.
In addition, it should not be ingested by nursing mothers because of the risk of transfer into breast milk and causing hypothyroidism in newborns. Patients with thyroid problems should be administered with caution because they have difficulty regulating iodine in the blood.
Iodoform is easily decomposed by light. Therefore, when storing iodoform, it should be stored in a light-shielded brown container away from direct sunlight. Iodoform can also be produced through a reaction called the "iodoform reaction."
The iodoform reaction is a reaction in which iodoform and carboxylic acid are formed by adding a strong base such as sodium hydroxide and a single iodine to a ketone or aldehyde with an acetyl group. In addition, secondary alcohols are oxidized by iodine and converted to ketones, so alcohols that would otherwise be oxidized to ketones with acetyl groups (methyl ketones) can also produce iodoform in this reaction.
The formation of iodoform in this reaction will result in a yellow precipitate in the flask or test tube. This phenomenon is used to detect ketones and aldehydes with acetyl groups. However, for actual structural analysis, instruments such as NMR and IR, which can determine the structure in more detail, are used.
In high school chemistry textbooks, the iodoform reaction is introduced as a method for structural analysis, but because the information obtained is limited and labor-intensive, the iodoform reaction is not used in structural analysis.
*Including some distributors, etc.
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Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
Infinium Pharmachem Pvt. Ltd., established in 2003 and headquartered in Gujarat, India, is a manufacturer specializing in the development, production, and global export of Iodine Derivatives. Its derivatives find applications in pharmaceutical, chemical, biotech, and related industries worldwide. Its product range encompasses Iodine, Iodate, Iodide, and Tolune which serve as key starting materials in pharmaceutical ingredient manufacturing. The company adheres to quality and sustainability, holding certifications such as ISO-9001-2015 and ISO-14001-2015. The company plays a significant role in the supply of synthesized impurities, metabolites, intermediates, and APIs through custom synthesis.
ALPHA CHEMICA, established in 1985, is an Indian manufacturer and supplier of laboratory reagents and fine chemicals, headquartered in Mumbai, Maharashtra. Their wide range of products includes high-performance liquid chromatography (HPLC), analytical reagent/guaranteed reagent (AR/GR), laboratory reagents (LRs), and fine chemicals, catering to life science and other specialty research. During the COVID-19 pandemic and its aftermath, ALPHA CHEMICA offered BactGO, a disinfectant solution with stabilized hydrogen peroxide using silver-based chemistry, and BaVi-X, a 75% alcohol-based hand sanitizer.
MUBY CHEMICALS, established in 1976, is a manufacturer and supplier of chemicals and excipients used in pharmaceuticals, cosmetics & personal care, agrochemical, and textile industries. Based in Ankleshwar, Gujarat, India, the company offers Shale gas hydraulic Fracturing Chemicals such as ammonium persulfate, diverting agents, inhibitors, ATMP phosphonate, and encapsulated gel breakers. Some food analytical reagent chemicals include benzyl alcohol, calcium oxide, boric acid, carbamide peroxide, and lithium carbonate. The company is GLP-approved, Kosher Certified, "REACH" Registered, and ISO-9001 Certified.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Prachi Pharmaceuticals Private Limited, started in 1987 in Mumbai, India, is a manufacturer and supplier of pharmaceutical ingredients such as iodine compounds, veterinary products, and active pharmaceutical ingredients. The company makes iodine compounds such as Potassium iodide, Sodium iodide, and Cuprous iodide. It also supplies active pharmaceutical ingredients like Thiamine hydrochloride, Povidone iodine, and Vitamin B1. The complex chemical solutions it makes and distributes include Camphor quinone, Closantel base, and Triphenyl methane.
Sisco Research Laboratories Pvt. Ltd. was established in 1975 and is headquartered in Mumbai, Maharashtra, India. The company manufactures highly complex reagents and biochemicals for public and private customers across industries with over 5000 products in different grades and packing sizes across product segments. The company’s 6 product categories are General Laboratory Chemicals & Solvents, Biochemicals & Specialty Fine Chemicals, Animal Cell Culture, Nanotechnology Products, Dehydrated Culture Media & Media Kits, and Biolit™ range of DNA and Protein tools.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Rishi Chemical Works is an Indian- based company that manufactures a comprehensive range of Pharmaceutical Chemicals and Industrial Fine Chemicals for industries all over the world. Their production facility is in Northern India, and their extensive product line includes Monopotassium Phosphate, Trisodium Phosphate, and Monosodium Phosphate, Potassium Acetate, among many more. They have a diverse range of plant and equipment, some of which are semi-automatic, to carry out various unit processes and operations.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
Ranking as of November 2024
Derivation MethodRank | Company | Click Share |
---|---|---|
1 | Infinium Pharmachem Pvt. Ltd. |
31.7%
|
2 | Parchem |
22.0%
|
3 | KANTO CHEMICAL CO.,INC. |
9.8%
|
4 | Prachi Pharmaceuticals Private Limited |
7.3%
|
5 | Alpha Chemica |
7.3%
|
6 | MUBY CHEMICALS |
7.3%
|
7 | SRL |
4.9%
|
8 | Shreeji Pharma International |
2.4%
|
9 | Otto Chemie Pvt. Ltd |
2.4%
|
10 | Kishida Chemical Co.,Ltd. |
2.4%
|
Derivation Method
The ranking is calculated based on the click share within the iodoform page as of November 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
Country | Number of Companies | Share (%) |
---|---|---|
India | 6 | 66.7% |
Japan | 2 | 22.2% |
United States of America | 1 | 11.1% |