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This section provides an overview for pentachlorothiophenol as well as their applications and principles. Also, please take a look at the list of 6 pentachlorothiophenol manufacturers and their company rankings. Here are the top-ranked pentachlorothiophenol companies as of December, 2024: 1.MilliporeSigma, 2.Santa Cruz Biotechnology, Inc..
Table of Contents
Pentachlorothiophenol, appearing as a white to grayish-brown powder, is known by its IUPAC name 2,3,4,5,6-pentachlorobenzenethiol or simply PCTP. In the US, it's recognized under the Toxic Substances Control Act (TSCA) as a persistent, bioaccumulative, and toxic (PBT) substance.
Used predominantly as an embrittlement agent for rubber, PCTP enhances the efficiency of the kneading process by reducing the rubber's molecular weight. This reduction lowers viscosity, aiding in the rubber mixing process and ensuring batch-to-batch viscosity uniformity. Despite its effectiveness, the classification of PCTP as a PBT substance has led to restrictions on its use in the US, with alternatives like bis(2-benzamidophenyl) disulfide, or BASS, being favored.
With the formula C6HCl5S and a molecular weight of 282.38, pentachlorothiophenol has a melting point of 231.5°C and a density of 1.7 g/ml. It's flammable, emits an unpleasant odor, and is insoluble in water. Notably, it's a metabolite of hexachlorobenzene, found in the excretions of animals exposed to the substance.
Produced by reacting hexachlorobenzene with sodium sulfide and sulfur or through the reaction of hydrogen sulfide with pentachlorophenol, PCTP synthesis involves acidic catalysts for efficiency.
As a skin corrosive and irritant, proper protective clothing and immediate washing off upon contact are crucial. It should be stored in light-shielded, tightly sealed glass containers in cool, well-ventilated areas to prevent degradation by light.
*Including some distributors, etc.
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Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Apollo Scientific Ltd, a subsidiary of Japan’s Central Glass Europe Limited, is a research chemicals manufacturer and supplier founded in 1993 and headquartered in Bredbury, United Kingdom. Performing chemical syntheses in their Manchester-based laboratories, Apollo Scientific offers a selection of over 100,000 chemical products, from fluorinated compounds to non-fluorinated building blocks, for research and industry applications. Their life science products include antibiotics and buffers, as well as customized products for stem cell, molecular biology, and proteomics research. Additionally, Apollo Scientific offers spectroscopy products, such as consumables for infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy, as well as mass spectrometry standards.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
Pharmaffiliates, established in 2001 and located in Gurgaon, India, is a manufacturer of pharmaceutical standards and services. The company provides Certified Reference Standards (CRS) used in analytical methods, as well as drug delivery systems like tablets, capsules, injectables, and deuterated compounds that aid in research and development, studying drug metabolism and pharmacokinetics. Pharmaffiliates also offers various services to the pharmaceutical industry, including custom synthesis, analytical research, stability studies, and formulation development.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | MilliporeSigma |
66.7%
|
| 2 | Santa Cruz Biotechnology, Inc. |
33.3%
|
Derivation Method
The ranking is calculated based on the click share within the pentachlorothiophenol page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
1 | 20.0% |
|
Japan
|
1 | 20.0% |
|
United Kingdom
|
1 | 20.0% |
|
Canada
|
1 | 20.0% |
|
India
|
1 | 20.0% |
