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This section provides an overview for hemin as well as their applications and principles. Also, please take a look at the list of 7 hemin manufacturers and their company rankings. Here are the top-ranked hemin companies as of December, 2024: 1.Central Drug House, 2.Jena Bioscience GmbH, 3.Cayman Chemical Company.
Table of Contents
Hemin, also known as protohemin, is an organic compound forming blue-violet or black-violet crystals or powder. Its IUPAC name is ferriprotoporphyrin Ⅸ chloride, and it has a CAS registration number of 16009-13-5.
Hemin is used as a pharmaceutical intermediate, particularly in treatments related to blood and hemoglobin. In medicine, it induces differentiation in cells of the erythrocyte lineage. As a trivalent iron complex of porphyrin with one chloride ion, hemin plays a vital role in hemoglobin production in blood.
Hemin is somewhat soluble in dimethyl sulfoxide, but extremely insoluble in ethanol and almost insoluble in water. It is sensitive to light, so glass is considered the safest storage container. For preservation, it should be stored away from light, and sealed in a refrigerator at 2~10℃.
Hemin is a trivalent iron complex of porphyrin with a chlorine ion bonded to it. Its molecular structure is pyramidal, with one ligand perpendicular to the square plane of porphyrin. The chemical formula of hemin is C34H32ClFeN4O4, and its molecular weight is 651.94. Porphyrin, the base structure of hemin, consists of four pyrrole rings joined by four carbons with a side chain attached to a closed porphine ring.
Hemin can be crystallized by heating blood with glacial acetic acid and salt. It is typically obtained as chlorohemin.
Hemin is the pigment in enzymes like catalase and peroxidase and is thought to be similar to the pigmented parts of cytochrome and cytochrome oxidase. It tests positive for benzidine staining, is used for hemoglobin detection, and induces erythroid differentiation in certain leukemia cells.
Hemin is also known as ferriprotoporphyrin IX chloride. Protoporphyrin IX, a related compound, has a molar mass of 562.658 and a structure with four methyl groups, two vinyl groups, and two propionate groups attached to the porphine ring.
*Including some distributors, etc.
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Cayman Chemical Company is a manufacturer of life science research products founded in 1979 in Ann Arbor, Michigan, USA. They offer a diverse array of analytical standards, reagents, and other products for research in cancer, oxidative injury, epigenetics, neuroscience, inflammation, as well as metabolism, and other areas. The company supplies small molecules, biochemicals, assay kits, antibodies, and proteins to research scientists across academic, biotechnology, and pharmaceutical institutions. Cayman Chemical Company holds dual accreditations to ISO/IEC 17025:2017 and ISO 17034:2016 by ANAB Accreditation Services.
Biosynth is a Swiss manufacturer of life science reagents established in 1966 and headquartered in Staad. The company sources and manufactures biochemical products such as carbohydrates, nucleosides, and enzyme substrates, as well as various peptides and biologics. They also operate as a contract manufacturer offering custom synthesis and manufacturing services for their clients in the pharmaceutical, diagnostic, food, and agrochemical sectors. Biosynth has regional sales offices and specialized facilities in Europe and North America, including in the Netherlands, United Kingdom, and United States.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Central Drug House |
21.4%
|
| 2 | Jena Bioscience GmbH |
19.0%
|
| 3 | Cayman Chemical Company |
16.7%
|
| 4 | nacalai |
14.3%
|
| 5 | Merck |
11.9%
|
| 6 | Biosynth |
9.5%
|
| 7 | MP Biomedicals |
7.1%
|
Derivation Method
The ranking is calculated based on the click share within the hemin page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
2 | 33.3% |
|
Switzerland
|
1 | 16.7% |
|
Japan
|
1 | 16.7% |
Germany
|
1 | 16.7% |
|
India
|
1 | 16.7% |
