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This section provides an overview for hexamethylenetetramine as well as their applications and principles. Also, please take a look at the list of 13 hexamethylenetetramine manufacturers and their company rankings. Here are the top-ranked hexamethylenetetramine companies as of December, 2024: 1.LGC Standards, 2.KANTO CHEMICAL CO.,INC., 3.India Fine Chemicals.
Table of Contents
Hexamethylenetetramine, a heterocyclic aliphatic amine, boasts the chemical formula C6H12N4. Commonly known as hexamine, urotropine, methenamine, and 1,3,5,7-tetraazaadamantane, this compound serves various industrial and medical purposes.
It is classified under several regulations: as a Class D substance, a "Class I designated chemical substance, and as an undesignated additive.
Hexamethylenetetramine finds its use in therapeutic settings, particularly for treating cystitis and urinary tract infections. It transforms into formaldehyde in the urine, which then exhibits antiseptic properties. While used as an antiseptic preservative in food products internationally, it is not utilized as a food preservative in Japan.
This compound appears as a colorless, odorless crystal or crystalline powder that sublimates at 280°C and ignites at 410°C. It is soluble in water, ethanol, and chloroform, but insoluble in benzene, acetone, and ether.
Hexamethylenetetramine's structure is a tetrahedral cage, similar to adamantane, with nitrogen atoms at the four vertices connected by methylene links. It features a molar mass of 140.186 g/mol and a density of 1.33 g/cm3 at 20°C.
Discovered by Alexander Butlerov in 1859, hexamethylenetetramine is produced industrially via the reaction of formaldehyde and ammonia.
It is instrumental in organic synthesis, notably in the Duff reaction for formylating aromatic rings, the Sommelet reaction for synthesizing aldehydes from benzyl halides, and the Delépine reaction for creating amines from alkyl halides.
Acting as an amine-like base, it undergoes protonation and N-alkylation. For instance, N-alkylation with 1,3-dichloropropene yields Quaternium-15, a quaternary ammonium salt consisting of cis and trans isomers.
*Including some distributors, etc.
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TRInternational Inc., founded in 1994 and headquartered in Edmonds, Washington, is a supplier of ingredients, raw materials, and services in North America. Its diversified product portfolio includes chemicals, rubber, and paints used in industries like metalworking, water treatment, and industrial cleaning. It has over 20 stocking and import points across the United States and offers additional services like custom manufacturing, contract packaging, and proprietary formulation. The company is SBA, WOSB, and LGBTBE certified, and in 2018, it was ranked number 70 in the Top 100 Chemical Distributors in North America.
Wego Chemical Group was founded in 1978 and headquartered in Great Neck, New York. WEGO is a full-service supplier and distributor of chemicals, minerals, and other raw materials to clients around the world. Markets and segments include agriculture & animal care, chemical & material manufacturing, construction & building materials, electronics, food & beverage, “household, industrial & institutional”, mining, oil & gas, personal care & pharmaceutical, paper & packaging, surface treatment, textiles, and water treatment.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
Mitsubishi Gas Chemical Company Inc., established in 1918 and headquartered in Tokyo, Japan, is a chemical manufacturer that makes basic and fine chemicals and functional materials. The company has two business divisions, namely basic chemicals and functional chemicals, and its product portfolio includes electronic industry cleaning agents, MMA derivatives, hydrogen peroxide, xylene separation products, and laminated materials for printed circuit boards. In 1981, the company took the first step towards geothermal power development, and today, it is involved in geothermal power projects in five locations, including the 50,000-kilowatt Sumikawa Geothermal Power Plant, where it commenced operations in 1995.
FujiFilm Wako Pure Chemical Corporation, founded in 1922 and headquartered in Osaka, Japan, is a manufacturer of laboratory chemicals, specialty chemicals, and clinical diagnostic reagents. The company has three business domains, namely laboratory chemicals, specialty chemicals, and clinical diagnostic reagents, and some of its products include biochemistry reagents, blood transfusion test drugs, battery materials, polymer-related materials, and general reagents. The products are useful in various fields, including electronic, cosmetic, polymeric, pharmaceutical, and medical care. It acquired Sibayagi Co. Ltd. in 2015 and provides custom manufacturing to meet customer requirements.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
LGC Standards Ltd., established in 1842, is a global British manufacturer and supplier of reference standards, headquartered in Teddington, Middlesex, with offices in 20 countries worldwide. As a subsidiary of LGC Group, the United Kingdom’s National Measurement Institute, LGC Standards also serves as the Government Chemist, providing expert opinions based on independent chemical and bioanalytical measurements. Under the business unit LGC Industrial, the company offers industrial measurement tools. Additionally, their subsidiaries, including Toronto Research Chemicals Inc (TRC) of Canada, LGC Mikromol™, and Dr. Ehrenstorfer™ of Germany, develop research tools, standards for pharmaceutical quality control, and reference materials for food and environmental analysis.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
CDN Isotopes Inc. has been a provider of deuterium-labelled compounds since its establishment in 1993. Located in Quebec, Canada, they supply researchers in the fields of medicine and science. They have over 3000 products and 98%of their orders are filled from stock. CDN isotopes have international distributors in over 40 countries and have continued to add new products to the market. They aim to provide customers with products at affordable prices while maintaining a large inventory of products.
India Fine Chemicals, founded in 1978 and headquartered in Taito-ku, Tokyo, Japan, is a distributor and supplier of chemicals, functional materials, food additives, as well as a planner and developer of health foods. The company offers an extensive range of products, including sodium vinylsulfonate 25% water solution, sodium cumene sulfonate, N-dimethyl-1,3-propanediamine, and diethyl sulfate. These chemicals serve various industries, including pharmaceuticals, agrochemicals, cosmetics, dyes, and flavors. The company also offers a range of services, including information about chemicals, a chemical search engine, product analysis, and contract development.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | LGC Standards |
17.4%
|
| 2 | KANTO CHEMICAL CO.,INC. |
12.4%
|
| 3 | India Fine Chemicals |
11.6%
|
| 4 | TRInternational, Inc. |
10.7%
|
| 5 | MITSUBISHI GAS CHEMICAL COMPANY, INC. |
8.3%
|
| 6 | Kishida Chemical Co.,Ltd. |
7.4%
|
| 7 | MilliporeSigma |
6.6%
|
| 8 | Merck |
6.6%
|
| 9 | Wego Chemical Group Inc |
5.8%
|
| 10 | MP Biomedicals |
5.0%
|
Derivation Method
The ranking is calculated based on the click share within the hexamethylenetetramine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
5 | 50.0% |
|
United States of America
|
3 | 30.0% |
|
United Kingdom
|
1 | 10.0% |
|
Canada
|
1 | 10.0% |
