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This section provides an overview for hfip as well as their applications and principles. Also, please take a look at the list of 12 hfip manufacturers and their company rankings. Here are the top-ranked hfip companies as of December, 2024: 1.Otto Chemie Pvt. Ltd, 2.Merck, 3.United Chemical Technologies..
Table of Contents
HFIP (1,1,1,3,3,3-hexafluoro-2-propanol), also known as hexafluoroisopropyl alcohol, is an organic compound with the chemical formula C3H2F6O. It is a clear, colorless liquid at room temperature, with a molecular weight of 168.04, a melting point of -4°C, and a boiling point of 59°C.
HFIP is primarily used as a solvent in organic synthesis and polymer processing as well as a synthetic raw material in pharmaceuticals and agrochemicals. It can dissolve polymers like polyamide, polyacrylonitrile, polyacetal, polyester, and polyketones, which are insoluble in many other solvents. HFIP is also used in biochemistry, particularly in liquid-phase peptide chemistry, and as a component in buffer solutions for ion-pair HPLC.
HFIP is synthesized mainly by hydride reduction of hexafluoroacetone or through catalytic hydrogenation.
Characterized by strong intramolecular polarization, HFIP's electron-withdrawing trifluoromethyl groups (-CF3) and electron-donating hydroxy group (-OH) enhance its ability to dissolve various substances. HFIP facilitates a range of chemical reactions, including Friedel-Crafts-type reactions and epoxidation reactions using hydrogen peroxide.
HFIP is sold primarily for research and development purposes in various volumes, ranging from small quantities (e.g., 10mL, 25g) to larger amounts (e.g., 500mL, 500g). It requires cold storage, typically at 25°C or lower.
HFIP is a corrosive compound and may cause skin irritation, serious eye damage, respiratory tract damage, and potential reproductive harm. It necessitates the use of protective equipment and adequate ventilation during handling. The compound is stable under normal storage conditions, but it should be stored away from high temperatures and direct sunlight to avoid reactions with strong oxidizing agents. Hazardous decomposition products include carbon monoxide, carbon dioxide, and halides.
*Including some distributors, etc.
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Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
Watanabe Chemical, established in 1951 and headquartered in Osaka, Japan, operates as a manufacturer and supplier of specialty chemicals and advanced materials. The company offers a diverse range of products including fluorinated chemicals, polyurethane additives, functional monomers, specialty resins, and surface modifiers. These products cater to various industries such as electronics, coatings, adhesives, and pharmaceuticals. It holds ISO 9001 certification, showcasing its adherence to quality management systems. The company also has its dark room lab with UV protection lamp to manufacture light-sensitive compounds.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
Chemical Enterprise, founded in India in 2004, is a B2B e-commerce platform that connects buyers and suppliers. The company offers an online marketplace that offers products such as personal care products, chemical supplies, electrical supplies, hospital and medical supplies as well as industrial supplies. It has more than 10 million registered users and above 90,000 product categories and provides detailed product descriptions for interested buyers to choose the right products as per their interest.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Otto Chemie Pvt. Ltd |
14.6%
|
| 2 | Merck |
14.6%
|
| 3 | Chemical Enterprise |
9.8%
|
| 4 | United Chemical Technologies. |
9.8%
|
| 5 | AnaSpec Inc. |
7.3%
|
| 6 | Regis Technologies, Inc. |
7.3%
|
| 7 | Eurisotop |
7.3%
|
| 8 | Alfa Aesar, Thermo Fisher Scientific. |
7.3%
|
| 9 | Watanabe Chemical |
7.3%
|
| 10 | Kishida Chemical Co.,Ltd. |
4.9%
|
Derivation Method
The ranking is calculated based on the click share within the hfip page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
United States of America
|
3 | 33.3% |
|
Japan
|
3 | 33.3% |
|
United Kingdom
|
1 | 11.1% |
France
|
1 | 11.1% |
|
India
|
1 | 11.1% |
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