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This section provides an overview for butylscopolamine as well as their applications and principles. Also, please take a look at the list of 7 butylscopolamine manufacturers and their company rankings. Here are the top-ranked butylscopolamine companies as of December, 2024: 1.Manus Aktteva Biopharma LLP, 2.Biosynth International, Inc., 3.MilliporeSigma.
Table of Contents
Butylscopolamine, also known as hyoscine-N-butylbromide, is a derivative of the alkaloid scopolamine. It has both parasympathomimetic and antispasmodic effects and is commonly used as a muscle relaxant and antispasmodic agent. By relaxing smooth muscle tone, it relieves spasms in the digestive system, alleviating symptoms such as indigestion and stomach pain. Classified as an atropine substitute and anticholinergic drug, it suppresses the parasympathetic nervous system and is synthesized to emulate atropine's effects. Its use requires caution due to varied side effects and contraindications.
Butylscopolamine is primarily used to control abdominal pain and stomach cramps, particularly caused by spasms in the digestive tract or uterus. Common side effects include impaired eye lens regulation, dry mouth, constipation, and headache. It is contraindicated in patients with glaucoma, bacterial diarrhea, and heart disease.
Butylscopolamine appears as a white to almost white crystalline powder with a faint characteristic odor. It has a molecular weight of 440.4 and is slightly soluble in water, but more soluble in alcohol and chloroform. As an anticholinergic agent, it competitively inhibits acetylcholine receptors, mainly muscarinic receptors, leading to reduced spasms and tension in the digestive system. It has limited passage into the central nervous system, acting predominantly on the peripheral nervous system. The drug is rapidly absorbed, metabolized primarily in the liver, and excreted through the kidneys.
Butylscopolamine is a tropane alkaloid derivative with a cyclic tropane skeleton and an ester functional group. It has a butyl group attached to scopolamine's structure, restricting its passage to the central nervous system and reducing central nervous system side effects. Typically, it exists as a quaternary ammonium salt.
Butylscopolamine is synthesized from scopolamine, which is extracted from plants like butterfly morning glory, jimsonweed, and mandrake. Although chemical synthesis of scopolamine is possible, plant extraction remains more common on an industrial scale. The N-alkylation process introduces a butyl group to scopolamine's nitrogen atom, creating butylscopolamine.
*Including some distributors, etc.
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Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Manus Aktteva Biopharma LLP, established in 2010 and headquartered in Ahmedabad, India, is a manufacturer, supplier, and exporter of pharmaceutical APIs, intermediates, and specialty chemicals. Their wide-ranging products cater to industries such as pharmaceutical, nutraceutical, and biotechnology. They offer Active Pharmaceutical Ingredients (APIs), the fundamental components used in various drug formulations, such as antibiotics, cardiovascular drugs, and anti-inflammatory drugs. The company also supplies specialty chemicals with unique properties applicable to diverse industries, from plastics to cosmetics manufacturing. Furthermore, the company offers custom synthesis services to meet the specific needs of their customers.
Alps Pharmaceutical Ind. Co. Ltd., established in 1947 and headquartered in Hida-shi, Japan, functions as a global pharmaceutical product manufacturer. Its product line comprises of active pharmaceutical ingredients (APIs), veterinary APIs, food additives, and feed additives. The company adopts a strategic warehousing approach, maintaining the Okamae warehouse with an extensive capacity of 8,000 tons for both products and raw materials. This robust supply chain strategy allows them to effectively hedge against risks related to weather-induced crop failures, market price fluctuations, and procurement challenges.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Biosynth International Inc. is a supplier of critical raw materials and services. The company was founded in 1966 with headquarters in Sraad, Switzerland. Biosynth has a global manufacturing and distribution network that supplies critical raw materials to the pharmaceutical and diagnostic industries across Europe, America, and Asia with local offices in the USA, China, the UK, Switzerland, Slovakia, and India. The company specializes in carbohydrates, nucleosides, peptides, neo-antigens, and enzyme substrates.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | MilliporeSigma |
42.9%
|
| 2 | Manus Aktteva Biopharma LLP |
14.3%
|
| 3 | Biosynth International, Inc. |
14.3%
|
| 4 | KANTO CHEMICAL CO.,INC. |
14.3%
|
| 5 | nacalai |
14.3%
|
Derivation Method
The ranking is calculated based on the click share within the butylscopolamine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
2 | 50.0% |
|
India
|
1 | 25.0% |
Switzerland
|
1 | 25.0% |
