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This section provides an overview for pyrene as well as their applications and principles. Also, please take a look at the list of 10 pyrene manufacturers and their company rankings. Here are the top-ranked pyrene companies as of December, 2024: 1.Zhengzhou Alfa Chemical Co.,Ltd, 2.Kishida Chemical Co.,Ltd., 3.Otto Chemie Pvt. Ltd.
Table of Contents
Pyrene, a polycyclic aromatic hydrocarbon (PAH) with the formula C16H10, is a key component of coal tar, presenting as colorless to pale yellow crystals. Notable for its insolubility in water and solubility in organic solvents, pyrene emits pale blue fluorescence when dissolved in benzene or ether. Its derivative, benzo(a)pyrene, is recognized for its carcinogenic properties.
Utilized as a fluorescent probe in biological research, pyrene allows for the visualization of DNA, proteins, and cell membranes due to its excimer emission in concentrated solutions. It also serves in the synthesis of naphthalenetetracarboxylic acid.
Pyrene exhibits sensitivity to light and stability at room temperature, with a melting point of 156.6°C and a boiling point of 404°C. This hydrophobic molecule is prone to oxidation and photodecomposition, posing environmental risks due to its potential for soil and sediment accumulation.
Featuring a planar structure of four fused six-membered aromatic rings, pyrene's conjugated system allows for extended π electron distribution. This facilitates π-π interactions, influencing its optical properties and stability.
Extracted primarily from coal tar through fractional distillation, pyrene can also be synthesized from petroleum products via catalytic cyclization, leveraging differences in boiling points for component separation.
*Including some distributors, etc.
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Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
Zhengzhou Alfa Chemical Co., Ltd. (ZACC) is a manufacturer of organic chemicals and catalysts established in 2010 and based in Jiaozuo, Henan. The company primarily produces pharmaceutical and organic intermediates as well as photoelectric materials for customers in life science, polymers, dyes, and metallurgy. The company's product lineup includes condensed ring compounds, heterocyclic compounds, COFS/MOFS, and metal catalysts. These supply client corporations such as Bayer AG, Pfizer Inc., and Sumitomo Chemical Company, Ltd. ZACC also offers gram- to ton-level contract synthesis and production services.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Henan Tianfu Chemical Co., Ltd., founded in 2009, is a Chinese chemical manufacturer and supplier based in Zhengzhou, Henan. The company has developed over 500 compounds, mostly for fine applications in manufacturing and life science. Their product range includes electronic chemicals, ultraviolet (UV)-curing materials, ionic liquids, and pharmaceutical materials. Additionally, Henan Tianfu has expanded into the fine chemical market, offering noble metal catalysts, organic phosphine ligands, and organic light-emitting diode (OLED) intermediates. They are also involved in the development of pesticides and medical intermediates, as well as the analysis and synthesis of electronic chemical materials.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
BOC Sciences is headquartered in Shirley, New York as a brand of BOCSCI Inc. The company is a developer, manufacturer, marketer, and distributor of premium chemicals, emphasizing small molecule synthesis, biosynthesis, purification, and characterization used in academia, pharmaceuticals, biotech, CDMO, material sciences, and agriculture industries, supporting research and production. The company’s products include thousands of inhibitors, nucleotides, metabolites, and isotope-labeled products. The company offers custom synthesis and manufacturing, analytical services, antibody-drug conjugate development, and strain engineering and fermentation services.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
National Analytical Corporation (NAC) is located in Mumbai, India. NAC was founded in 2009 as a distributor of laboratory grade chemicals used in numerous industries. NAC’s chemical offerings include biochemical & reagents such s Prunetin and 1,2-dipalmitoly-rac-glycerol, analytical grade chemicals such as chicoric acid and Vitamin E solutions, laboratory chemicals such as formic acid and nitric acid, gas chromatography chemicals such as Aalborg mass flowmeter battery kits and DEX 225, reference standard chemicals such as Palladium in HNO3, oral solid dosage forms, such as cellulosic and protect film coating systems, parenteral dosage forms, beverage & nutrition, and coating chemicals.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Zhengzhou Alfa Chemical Co.,Ltd |
27.8%
|
| 2 | Kishida Chemical Co.,Ltd. |
16.7%
|
| 3 | Otto Chemie Pvt. Ltd |
11.1%
|
| 4 | KANTO CHEMICAL CO.,INC. |
11.1%
|
| 5 | Sourcechem Co.,Ltd. |
5.6%
|
| 6 | Henan Tianfu Chemical Co.,Ltd |
5.6%
|
| 7 | NATIONAL ANALYTICAL CORPORATION |
5.6%
|
| 8 | BOC Sciences |
5.6%
|
| 9 | nacalai |
5.6%
|
| 10 | Merck |
5.6%
|
Derivation Method
The ranking is calculated based on the click share within the pyrene page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
3 | 42.9% |
|
China
|
2 | 28.6% |
|
India
|
2 | 28.6% |
