10 Vinblastine Manufacturers in 2024
This section provides an overview for vinblastine as well as their applications and principles. Also, please take a look at the list of 10 vinblastine manufacturers and their company rankings. Here are the top-ranked vinblastine companies as of November, 2024: 1.Manus Aktteva Biopharma LLP, 2.Chemcopia Ingredients Pvt Ltd, 3.Nextwell Pharmaceutical Private Limited.
Table of Contents
What Is Vinblastine?
Vinblastine is a compound classified as a vinca alkaloid, a type of alkaloid isolated from the plant Nichinichiwa.
Its molecular weight is 810.975 and its molecular formula is C46H58N4O9. The compound is characterized by its white to light yellow powdery color and extremely low water solubility. It is virtually insoluble in water and alcohols and soluble in organic solvents such as DMSO and ethyl acetate.
Vinblastine is used as an antineoplastic agent in the treatment of cancer because of its ability to inhibit cell proliferation by blocking microtubule polymerization during the M phase of cell division. Vinblastine, used as a drug, is generally in a sulfate structure to improve stability and solubility.
Uses of Vinblastine
Vinblastine is a type of antineoplastic agent used in the treatment of cancer. After being administered intravenously, vinblastine is taken up into the cells by taking advantage of its high liposolubility.
It then acts specifically in the M phase of the cell cycle, preventing cancer cells from dividing by inhibiting the binding of tubulin, a protein that makes up microtubules within the cell. Vinblastine is one of the leading anticancer drugs and is used against a wide range of cancer types, including leukemia, malignant lymphoma, breast cancer, ovarian cancer, and lung cancer.
Because vinca alkaloids are characterized by their tendency to cause neuropathy, patients should be aware of numbness in the fingers and toes and abnormal sensations in the skin when Vinblastine is administered.
Properties of Vinblastine
Vinblastine is a white to light yellow powder. It has extremely low solubility and is virtually insoluble in solvents such as water, ethanol, and methanol. On the other hand, it is soluble in organic solvents such as DMSO, dichloromethane, and ethyl acetate, and is generally used in these solvents.
Vinblastine is not metabolized in vivo and is excreted directly into the urine, and its pharmacokinetics are believed to involve fibroblast growth factor receptor (FGFR) 3. It is also a highly toxic alkaloid and should be used with caution.
Structure of Vinblastine
The molecular structure of Vinblastine is an indole alkaloid with an indole skeleton in its basic structure. Its chemical formula is C46H58N4O9 and its molecular weight is 810.97.
It has a complex structure consisting of several chiral carbon atoms and numerous oxygen and nitrogen atoms, and has several functional groups such as alkyl and carboxyl groups on its side chains. It has several functional groups, such as alkyl groups and carboxyl groups on its side chains. Due to its high liposolubility, vinblastine is taken up into cells and binds to tubulin, a dimer, thereby exerting anticancer effects and inhibiting cancer cell proliferation.
Vinblastine is extracted from plants, but many optical isomers are known to exist in natural products. Therefore, there is a need to develop methods for the synthesis and purification of purely active and advantageous optical isomers.
However, the current challenge is the low yield due to the difficulty of synthesis caused by the complex structure. There is a continuing need to develop more efficient synthetic methods for Vinblastine.
Other Information on Vinblastine
How Vinblastine Is Produced
Vinblastine is isolated from Madagascar periwinkle (Catharanthus roseus) along with its precursors (catharanthine and vindoline). Vinblastine is extracted from leaves, stems, and roots, and is isolated by chromatographic purification.
Due to its complex three-dimensional structure, the many steps involved in its synthesis, and low yields caused by byproducts, it is difficult to synthesize vinblastine on an industrial scale, and extraction from natural products is the main source of vinblastine.
However, because plant-extracted Vinblastine and its precursors contain optical isomers that are unfavorable for activity, enantioselective total synthesis using chiral agents (sharpless catalysts) and controlled reaction temperatures have recently received considerable attention.
List of 10 Vinblastine Manufacturers
*Including some distributors, etc.
Sort by Features
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- Company Size: largest first
- Year Founded: oldest first
- Year Founded: earliest first
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- India
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Pharmaffiliates
Vinblastine
Manufacturer Overview
Pharmaffiliates, established in 2001 and located in Gurgaon, India, is a manufacturer of pharmaceutical standards and services. The company provides Certified Reference Standards (CRS) used in analytical methods, as well as drug delivery systems like tablets, capsules, injectables, and deuterated compounds that aid in research and development, studying drug metabolism and pharmacokinetics. Pharmaffiliates also offers various services to the pharmaceutical industry, including custom synthesis, analytical research, stability studies, and formulation development.
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Manus Aktteva Biopharma LLP
Vinblastine
Manufacturer Overview
Manus Aktteva Biopharma LLP, established in 2010 and headquartered in Ahmedabad, India, is a manufacturer, supplier, and exporter of pharmaceutical APIs, intermediates, and specialty chemicals. Their wide-ranging products cater to industries such as pharmaceutical, nutraceutical, and biotechnology. They offer Active Pharmaceutical Ingredients (APIs), the fundamental components used in various drug formulations, such as antibiotics, cardiovascular drugs, and anti-inflammatory drugs. The company also supplies specialty chemicals with unique properties applicable to diverse industries, from plastics to cosmetics manufacturing. Furthermore, the company offers custom synthesis services to meet the specific needs of their customers.
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Taj Pharmaceuticals Limited
Vinblastine
Company Overview
Taj Pharmaceuticals Limited, established in 1995 and headquartered in Mumbai, India, is a global manufacturer and supplier of generic medicines, healthcare, and other products. The company markets more than 500 branded and 4600 generic compositions to consumers in over 40 countries and territories across the globe. Its products cover a vast array of therapeutic categories, and offers an extensive range of dosage forms and delivery systems including oral solids, controlled-release, and steriles. Some of its offerings are diabetic care products, insulin, and growth hormones. The company holds the ISO 9001:2000 certification for its quality management system.
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Intelicure Lifesciences
Vinblastine
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WHITE SWAN PHARMACEUTICAL
Vinblastine Injection
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Nextwell Pharmaceutical Private Limited
Vinblastine Injection
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Chemcopia Ingredients Pvt Ltd
Vinblastine
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PV Pharma Healthcare Pvt. Ltd
Vinblastine
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BioCrick
Vinblastine
Company Overview
BioCrick Co., Ltd is located in Chengdu Tianfu Life Science Park in Sichuan Province, China. The company creates a natural product library which provides small molecular compounds with potential biological and pharmacological activities for pharmaceutical, agricultural, and biotechnology companies worldwide. The company’s database includes more than 8,000 compounds collected from natural sources such as as medicinal plants, herbs, fungus, and microbes. The company also a provider of peptides and lab reagents for biological research, carrying a product line in apoptosis, epigenetic, and cancer biology.
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Vinblastine Manufacturer Ranking
*Including some distributors, etc.Ranking as of November 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Manus Aktteva Biopharma LLP |
31.2%
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| 2 | Chemcopia Ingredients Pvt Ltd |
15.6%
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| 3 | Nextwell Pharmaceutical Private Limited |
10.4%
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| 4 | BioCrick |
10.4%
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| 5 | Pharmaffiliates |
7.8%
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| 6 | Intelicure Lifesciences |
6.5%
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| 7 | WHITE SWAN PHARMACEUTICAL |
6.5%
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| 8 | PV Pharma Healthcare Pvt. Ltd |
5.2%
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| 9 | Taj Pharmaceuticals Limited |
3.9%
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| 10 | CYGNUS HEALTHCARE SPECIALITIES PVT. LTD. |
2.6%
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Derivation Method
The ranking is calculated based on the click share within the vinblastine page as of November 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
- Pharmaffiliates: 2001 (23 years ago)
Company with a History
- Pharmaffiliates: 2001 (23 years ago)
Global Distribution of Vinblastine Manufacturers by Country
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
India
|
4 | 100.0% |
