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This section provides an overview for vincristine as well as their applications and principles. Also, please take a look at the list of 14 vincristine manufacturers and their company rankings. Here are the top-ranked vincristine companies as of December, 2024: 1.Manus Aktteva Biopharma LLP, 2.LGM Pharma, 3.ZUCHE PHARMACEUTICALS PVT. LTD..
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1993~2019: Engaged in pharmaceutical research and development and analysis of various biological samples at the Pharmaceutical Research Institute of Japan Kayaku Co., Ltd. He is also in charge of facility management as a dangerous goods handler and radiation handling chief.
2019: Moved to another company in the same industry and has been in charge of similar work until now.
He also writes, translates, and edits specialized books.
Linkedin: https://www.linkedin.com/in/makoto-niwa-25331040/
Researchmap: https://researchmap.jp/0000-0002-2355-1222/
Vincristine is an anticancer drug developed by Eli Lilly and Company, an American pharmaceutical company.
It is also known by the trade name Oncovin and is manufactured and marketed in Japan by Nippon Kayaku Co. It is a commonly used drug for hematologic tumors and is listed on the World Health Organization's (WHO) Model List of Essential Medicines as an important drug.
Vincristine is found in the oleander plant in Nichinichiwa, and is chemically classified as a vinca alkaloid, a plant alkaloid. As an anticancer drug, it is classified as a microtubule polymerization inhibitor and is a deleterious drug.
As a drug, it is only prescribed by a physician and is administered intravenously. It is usually supplied as Vincristine sulfate. The CAS number is 2068-78-2.
Vincristine is used as an anticancer agent. As a pharmaceutical product, Vincristine is indicated in Japan as of 2022 for the treatment of leukemia, malignant lymphoma pediatric oncology, multiple myeloma malignant astrocytoma, glioma with oligodendroglioma component in combination with other antineoplastic agents, and pheochromocytoma.
Vincristine is also used as an anti-tumor agent for experimental research and as a reagent in cytoskeletal research when microtubule polymerization inhibition is performed. It is also sold as a reagent for experimental studies.
Vincristine is sometimes used in the treatment of malignant lymphoma in dogs and other pet animals. In recent years, there has been a growing awareness of the possibility of somehow treating cancer in pet animals (with the hope of prolonging their lives).
Although Vincristine is not an official veterinary drug, there are currently no anti-cancer drugs for animals. Therefore, human drugs may be used by veterinarians.
Vincristine's mechanism of action is the inhibition of microtubule polymerization. Mitosis of cells requires the formation of a spindle. The spindle is formed by the attachment of microtubules to chromosomes and the polymerization and depolymerization of microtubules to form a spindle thread.
Vincristine binds to microtubules and causes abnormalities in the structure and function of the spindle, resulting in the arrest of mitosis in the mid-mitotic (M) stage of the cell. The mitotic arrested cells are induced to apoptosis.
In this way, tumor cell proliferation is suppressed and the cells are killed. However, since it also inhibits cell division of normal cells, the concern is that it affects not only tumor cells but also normal cells. This can cause side effects.
Vincristine also inhibits cell division of normal cells, which may cause side effects such as hair loss (alopecia) and a decrease in white blood cell count (myelosuppression). This is a common characteristic of anticancer agents.
Peripheral neuropathy is also known as a frequent side effect. Clinically, this is felt as numbness in the hands and feet and loss of sensation in the fingers. This symptom can have a significant impact on the lives of those undergoing treatment, such as difficulty in performing personal tasks and burns or injuries due to lack of sensation.
There is also a high likelihood that the condition will worsen with continued administration. Therefore, dosage should be reduced or discontinued when this symptom is observed.
Peripheral neuropathy is also seen with other phytoalkaloid microtubule polymerization inhibitors and is thought to be due to the drug also binding to the microtubules of peripheral nerves, causing axonal degeneration. Another common side effect is constipation.
Vincristine is often used in combination with other anticancer agents that have different mechanisms of action. The objective is to inhibit the growth of cancer effectively by having multiple actions work simultaneously.
For example, in lymphoma, it is used in combination with cyclophosphamide, which methylates DNA, doxorubicin, which gets between DNA structures, and oxaliplatin, which forms cross-links in DNA. Because anticancer drugs have strong side effects, the actual dosage of combination therapy used is carefully considered and determined.
*Including some distributors, etc.
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LGM Pharma, established in 2005 and headquartered in Florida, USA, is a manufacturer of API sourcing and drug product lifecycle solutions. The company specializes in complex drug development projects such as 505(b)(2) submissions and offers contract development and manufacturing services in the pharmaceutical industry. Its active pharmaceutical ingredients are used for injectable formulations, transdermal patches, and sublingual drug deliveries. It also covers formulation development, stability studies, and commercial production for injectables, transdermals, and inhalation therapies. With cGMP systems aligned with ICH Q7 standards, the company serves the biotech, specialty pharma, and generics sectors.
Manus Aktteva Biopharma LLP, established in 2010 and headquartered in Ahmedabad, India, is a manufacturer, supplier, and exporter of pharmaceutical APIs, intermediates, and specialty chemicals. Their wide-ranging products cater to industries such as pharmaceutical, nutraceutical, and biotechnology. They offer Active Pharmaceutical Ingredients (APIs), the fundamental components used in various drug formulations, such as antibiotics, cardiovascular drugs, and anti-inflammatory drugs. The company also supplies specialty chemicals with unique properties applicable to diverse industries, from plastics to cosmetics manufacturing. Furthermore, the company offers custom synthesis services to meet the specific needs of their customers.
Rewine Pharmaceutical, founded in 2014 and headquartered in Surat, Gujarat, India, is a manufacturer, exporter, and supplier of generic and branded finished pharmaceutical formulations. The company's main products are therapeutic medicines, such as those that deal with bacterial infections and fungus. Sample products include anti-bacterial creams, antacids, and anti-fungal solutions. Its product range also includes Himalayan herbal products, allopathic products, and modern pharmaceuticals. The company primarily serves wholesale buyers, exporting the majority of its products to the USA, the UK, and Europe.
Weefsel Pharma, founded in 2014 and headquartered in Surat, Gujarat, India, is a manufacturer, supplier, and exporter of pharmaceuticals. The company's wide range of products includes tablets, capsules, and oral suspensions. It also produces inhalers, lotions, and condoms, and the drugs it produces include lidocaine, sildenafil, and dicnoflenac. These products are distributed through hospitals, medical centers, and drug stores. The company produces its own generic brands as well as working with original manufacturers to supply branded medicinals and drugs.
Jigs Chemical was established in 1998 and is based in India with global offices in the USA, UK, Canada, and Australia. Jigs Chemical is a manufacturer, distributor, and marketing & sales provider for organizations in India, specializing in chemicals and active pharmaceutical ingredients for pharmaceutical, agriculture, ceramics, metal treatment, and other industries. Jigs Chemical helps facilitate international customers to obtain chemicals from India, providing import and export assistance. Jigs Chemical’s product catalog includes over 40000 active pharmaceutical ingredients, commonly called APIs, their respective intermediates, and other chemicals.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Manus Aktteva Biopharma LLP |
24.1%
|
| 2 | LGM Pharma |
14.8%
|
| 3 | ZUCHE PHARMACEUTICALS PVT. LTD. |
14.8%
|
| 4 | Jigs chemical |
11.1%
|
| 5 | Apollo Pharmacy |
5.6%
|
| 6 | WHITE SWAN PHARMACEUTICAL |
5.6%
|
| 7 | Weefsel Pharma |
5.6%
|
| 8 | MEDZEEL LIFESCIENCE |
3.7%
|
| 9 | The Indian Pharma |
3.7%
|
| 10 | Rewine Pharmaceutical |
3.7%
|
Derivation Method
The ranking is calculated based on the click share within the vincristine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
5 | 83.3% |
|
United States of America
|
1 | 16.7% |
