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This section provides an overview for vitamin a as well as their applications and principles. Also, please take a look at the list of 10 vitamin a manufacturers and their company rankings. Here are the top-ranked vitamin a companies as of December, 2024: 1.RAJVI ENTERPRISE, 2.Lifevision Healthcare, 3.Hugestone Enterprise Co., Ltd..
Table of Contents
The term “Vitamin A” refers to a group of related compounds, but most commonly to a fat-soluble vitamin called retinol (Vitamin A1), which is an alcohol.
In a broader sense, the term can also include the aldehyde form retinal, the carboxylic acid retinoic acid, and their 3-dehydro forms (called vitamin A2), as well as related substances and derivatives.
Retinol, the principal substance, has the chemical formula C20H30O, a molecular weight of 286.4516, and CAS number 68-26-8. Its melting point is 62-64°C and boiling point is 137-138°C.
It is insoluble in water, susceptible to oxidation, and easily decomposed by air, oxygen, moisture, heat, and light. It is an essential nutrient that promotes skin cell differentiation and is known to play a role in maintaining healthy skin and mucous membranes.
Vitamin A is a generic term that refers to retinol, retinal, and retinoic acid, but most vitamin A in human blood is retinol. Retinol is an essential nutrient and has uses as a dietary supplement and in pharmaceuticals because it promotes skin cell differentiation.
Among vitamin A, retinoic acid has been reported to have many skin-related effects and is approved as a treatment for acne in the United States. In Japan, the indication labeling of retinol as a wrinkle-improving agent in cosmetics has been approved as a quasi-drug.
Retinol (alcohol form), called vitamin A1, is oxidized to retinal (aldehyde form) and retinoic acid (carboxylic acid), in that order. In fact, these substances are the main body of the active action. These are broadly classified as Vitamin A, and their analogues are called retinoids. Retinal is involved in vision, and retinoic acid is involved in the regulation of gene expression.
There are other substances that, when ingested, produce the physiological effects of vitamin A in the body. These include retinyl fatty acid esters and carotenoids classified as vitamin A.
There are approximately 50 types of provitamin A, including β-carotene. The carotenoids are unique in that they do not cause overdose; β-carotene is broken down in the body in the absorptive epithelial cells of the small intestine or in the liver and kidneys to form vitamin A.
Generally, retinyl fatty acid esters are found in animal products, while vitamin A carotenoids are mainly found in plant products.
Vitamin A is widely available as a dietary supplement and as a pharmaceutical agent because it is an essential nutrient. Because it is a fat-soluble vitamin, capsules are often used as the dosage form.
However, it is important to note that excessive intake of retinol can cause dizziness, nausea, headache, coma, and may be fatal. In addition, excessive intake by pregnant women may lead to birth defects in the fetus.
Vitamin A is also used in experimental research. In addition to being sold as pure retinol, it may also be available as retinol acetate or as retinol palmitate standard solution for HPLC.
As an essential nutrient vitamin A, is essential for the proper functioning of the human body. For example, retinol is an essential nutrient that promotes skin cell differentiation and is used to protect retinal cells. When retinol is deficient, rhodopsin in photoreceptor cells ceases to function and night blindness develops.
Rhodopsin is a photopigment that is important in triggering light-induced excitation (optokinesis) in photoreceptor cells. It is also necessary for the immune system, the regulation of genetic information in DNA reproductive functions, and helps the heart, lungs, kidneys, and other organs to function properly.
*Including some distributors, etc.
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Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
Devlife Corporation Private Limited, headquartered in Mumbai, India, and established in 2005, is an exporter and manufacturer of customized finished formulations and Micronesian bulk drugs. The company offers an array of product lines featuring various dosage forms, including soft gelatin capsules, allopathic cough syrup, pain relief drugs and pharmaceuticals, large-volume parenterals, and liquid injectables. The company caters to various segments of the life science industry, including biotech, clinical research, and pharmaceutical sectors. It is one of the WHO GMP injection manufacturers in India.
SDA Products, founded in Mumbai, Maharashtra, in 1997 is a manufacturer and supplier of Veterinary Products. The company's product portfolio includes Bentonite Powder, Copper Sulphate Powder, Dextrose Monohydrate Powder, Ferrous Sulphate Crystals and Ferrous Sulphate Powder. Their products are used in industries such as Food and Beverage, Pharmaceutical and Biotechnology, Chemical and Petrochemical, Environmental Testing and healthcare. The company has a global distribution network, a customer support center, R&D center and quality control services.
Botanic Healthcare LLC is a manufacturer and supplier of herbal extracts and phytochemicals. It is headquartered in Pune, India, and was established in 2002. The company specializes in developing and manufacturing plant-derived active principles for complementary health medicine. Its wide range of herbal extracts includes standardized extracts, crude extracts, and essential oils. Botanic Healthcare also offers phytochemicals such as vitamins, minerals, and amino acids. The company's products are used in industries such as pharmaceuticals, cosmetics, dietary supplements, and food. Botanic Healthcare The company's devotion extends to providing quality products, transparency in ingredient sourcing, and educational resources.
Foodchem was founded in 2006 in Shanghai, China. The company is ISO 9001 certified and is a producer, distributor, R&D provider, and marketer of specialty and standard food additives and ingredients to pharmaceutical, cosmetic, nutrition, and chemical industries around the world through distributors and self-managed warehouses. The company operates through four product segments: Food Ingredients, Feed Additives, Industrial Chemicals, and Active Pharmaceutical Ingredients. Certain categories include Kosher and Halal-certified products and products meeting other dietary restrictions.
BASF Personal Care and Nutrition GmbH, headquartered in Ludwigshafen, Rhineland-Palatinate, Germany, is a supplier of ingredients for the personal care industry. Its product range encompasses skincare, hair care, oral care, and sun care ingredients. The company provides comprehensive support for product development processes and offers formulations that showcase its ingredients for various applications. Among its offerings are emollients such as Cyclopentasiloxane, Dimethicones, and Mineral Oils. Its products have diverse applications, spanning from gentle creams and conditioning shampoos to cosmetics, detergents, and cleaning agents.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | RAJVI ENTERPRISE |
17.2%
|
| 2 | Lifevision Healthcare |
12.1%
|
| 3 | Hugestone Enterprise Co., Ltd. |
12.1%
|
| 4 | Botanic Healthcare LLC |
11.2%
|
| 5 | Parchem |
10.3%
|
| 6 | BASF Personal Care and Nutrition GmbH |
9.5%
|
| 7 | SDA Products |
9.5%
|
| 8 | Devlife Corporation Private Limited |
7.8%
|
| 9 | Divi’s Laboratories Ltd. |
5.2%
|
| 10 | Foodchem International Corporation |
5.2%
|
Derivation Method
The ranking is calculated based on the click share within the vitamin a page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
5 | 55.6% |
|
China
|
2 | 22.2% |
|
United States of America
|
1 | 11.1% |
|
Germany
|
1 | 11.1% |
