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This section provides an overview for biotin as well as their applications and principles. Also, please take a look at the list of 13 biotin manufacturers and their company rankings. Here are the top-ranked biotin companies as of December, 2024: 1.AdvaCare Pharma USA, 2.Nutra Business LLC, 3.Salus Nutra Inc.
Table of Contents
Biotin is a nutrient, commonly known as vitamin B7 or vitamin H.It is a substance that is synthesized in plants and also by the microbiota of the large intestine in humans. It is known to be involved in maintaining healthy skin and mucous membranes, as well as in the health of nails and hair.
A deficiency of biotin leads not only to rough skin, but also to mental health problems, such as symptoms of depression. It is known to be abundantly contained in mushrooms and meat, and a daily intake of 50 µg can be achieved by maintaining a well-balanced diet.
The most common use of biotin is in medicines related to skin conditions. Because of its reported ability to prevent skin inflammation, biotin is sometimes prescribed as a supplement for eczema, contact dermatitis, acne, and other skin conditions.
Biotin has a melting point of 232-233°C. It is stable against acids, alkalis, and light, but unstable against heat.
Biotin is soluble in water and alcohol, but insoluble in organic solvents. It is partially lost during food processing.
Biotin is a white, needle-like crystal with the chemical formula C10H16N2O3S and a molecular weight of 244.31. It is also a component of coenzyme A (CoA).
Biotin is abundant in meats and other foods, but it is important to consume it in its least processed form possible, as its residual rate varies depending on how it is processed and stored. If it is still not possible to consume biotin, it can be obtained through supplements.
Biotin is an essential nutrient for all organisms, but only some microorganisms, molds, and plants can biosynthesize it.
Biotin in food is released in its free form by the enzyme biotinidase, bound to proteins such as biocytin and biotinyl peptides. Biotin in supplements is already in its free form and is therefore easily absorbed.
Free biotin is absorbed in the small intestine. It is then turned into a coenzyme for carboxylase by holocarboxylase and synthetic enzymes.
Biotin acts as a coenzyme for carboxyltransferase. A group of enzymes that have biotin as a coenzyme is called the biotin enzyme group.
Examples of biotin enzymes are pyruvate carboxylase and acetyl CoA carboxylase. Pyruvate carboxylase is involved in sugar metabolism, while acetyl-CoA carboxylase is involved in fatty acid synthesis.
Others include propionyl CoA carboxylase and 3-methylcrotonyl CoA carboxylase. Propionyl CoA carboxylase is involved in amino acid and fatty acid metabolism, while 3-methylcrotonyl CoA carboxylase is an enzyme involved in the metabolism of leucine, a type of amino acid.
Avidin in raw egg white will bind very strongly to biotin; by binding biotin to the target molecule, it becomes a landmark and can be detected by avidin. This method is used in blood tests. In some cases, high blood levels of biotin from over-supplementation can lead to erroneous blood test results for thyroid hormones and vitamin D3.
Serum biotin levels are not good indicators of inadequate biotin intake. Rather, the biotin levels are measured in order to assess the accuracy of other serology results.
Biotin cannot be biosynthesized in mammals. Synthesis by intestinal bacteria alone is likely to be insufficient to meet the required amount, so it must be obtained from food. Biotin is found in a wide variety of foods and a deficiency does not occur with a healthy diet. However, long-term use of antibiotics theoretically increases the dietary requirement for biotin.
Furthermore, because biotin is a water-soluble vitamin, it is easily excreted in urine when taken in excess. There are no reported health problems caused by overdose and no upper tolerable limit has been established.
*Including some distributors, etc.
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AdvaCare Pharma USA LLC, founded in 2014, is an American pharmaceutical manufacturer and supplier based in Cheyenne, Wyoming. The company specializes in a wide range of products, including over-the-counter (OTC) medicines, supplements, antimalarial tablets, injections, and oral suspensions. They also offer oncology tablets, injections, and powder for injections, as well as veterinary products and medical devices like injection instruments, diagnostic detection instruments, and skin and wound care products. AdvaCare's products are available under various brands, such as AmoxiCare™ for amoxicillin capsules and AdvaLife™ for supplements.
Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
Manus Aktteva Biopharma LLP, established in 2010 and headquartered in Ahmedabad, India, is a manufacturer, supplier, and exporter of pharmaceutical APIs, intermediates, and specialty chemicals. Their wide-ranging products cater to industries such as pharmaceutical, nutraceutical, and biotechnology. They offer Active Pharmaceutical Ingredients (APIs), the fundamental components used in various drug formulations, such as antibiotics, cardiovascular drugs, and anti-inflammatory drugs. The company also supplies specialty chemicals with unique properties applicable to diverse industries, from plastics to cosmetics manufacturing. Furthermore, the company offers custom synthesis services to meet the specific needs of their customers.
Global Pharma is an exporter and channel partner of API manufacturers and pharmaceutical raw materials and products across the globe. It is headquartered in Mumbai, India, and was established in 2003. The company distributes sevral types of pharmaceutical products, including generic drugs, branded drugs, and over-the-counter medications. Some of its popular products are Crocin, Viagra, Dolo, and Calpol. Global Pharma also provides technical support and training services. Its products are used in many hospitals, clinics, and pharmacies in India and the around the world.
Sandoo Pharmaceuticals and Chemicals Co., Ltd., founded in 2009 and situated in Ningbo, Zhejiang Province, China, is a manufacturer of pharmaceuticals and chemicals. Its diverse product portfolio encompasses active pharmaceutical ingredients (API), anti-cancer substances, antiviral drug intermediates, fine chemicals, and food additives, along with critical intermediates for polypeptide compounds. The company maintains a stringent adherence to FDA-approved and GMP-certified sources for its supplies which are exported to over 20 countries.
Supplement Factory Ltd was established in 2011 in Ashford, England, and is a manufacturer of private-label supplements such as tablets, duo caps, gummy supplements, and capsules for these industries: health and lifestyle, wellness, sports nutrition, and beauty. The company manufactures toothpaste tablets, whole protein, capsule shells, blister packs, and antioxidant gummies from ingredients such as activated charcoal, evening primrose oil, coconut water, ginkgo biloba, and glucomannan konjac. It is BRCS Food Safety, Halal, and NSF certified.
Samex Overseas, located in Gujrat, India,and established in 2002, is an exporter, manufacturer, and supplier of active pharmaceutical ingredients (API), bulk drug intermediates, and veterinary medicines, including IVERMECTIN EP. The company has a diverse product portfolio that includes corticosteroids, hormones and anabolic steroids, inhibitors, peptides, and other bulk drug intermediates. It also offers various active pharmaceutical ingredients, such as ivermectin, benfotiamine, dapoxetine, mupirocin, stanazolol, and more. The company serves various clients in the field of pharmaceuticals and nutraceuticals, including private, institutional, commercial, and corporate customers.
Belle Chemical LLC, based in Montana, United States, and established in 2020, is a chemical manufacturer and distributor operating in e-commerce, vitamins and supplements, and oilfield service. The company plays a pivotal role in producing and supplying a range of essential chemical products, including activated charcoal, food-grade sodium bentonite clay, hand sanitizer-grade ethanol, medical-grade propylene glycol, and medical-grade vegetable Vegetable Glycerin. The company's products are conveniently available through major e-commerce platforms like Amazon.com, Walmart.com, Ebay.com, Bonanza.com, and Jet.com.
Foodchem was founded in 2006 in Shanghai, China. The company is ISO 9001 certified and is a producer, distributor, R&D provider, and marketer of specialty and standard food additives and ingredients to pharmaceutical, cosmetic, nutrition, and chemical industries around the world through distributors and self-managed warehouses. The company operates through four product segments: Food Ingredients, Feed Additives, Industrial Chemicals, and Active Pharmaceutical Ingredients. Certain categories include Kosher and Halal-certified products and products meeting other dietary restrictions.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | AdvaCare Pharma USA |
19.4%
|
| 2 | Nutra Business LLC |
15.3%
|
| 3 | Salus Nutra Inc |
9.2%
|
| 4 | Manus Aktteva Biopharma LLP |
9.2%
|
| 5 | Supplement Factory Ltd |
8.2%
|
| 6 | Parchem |
8.2%
|
| 7 | Foodchem International Corporation |
7.1%
|
| 8 | ETChem |
5.1%
|
| 9 | Krishana Enterprises |
5.1%
|
| 10 | Global Pharma |
5.1%
|
Derivation Method
The ranking is calculated based on the click share within the biotin page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
4 | 36.4% |
|
United States of America
|
3 | 27.3% |
|
China
|
3 | 27.3% |
|
United Kingdom
|
1 | 9.1% |
