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This section provides an overview for hydroxybenzoic acids as well as their applications and principles. Also, please take a look at the list of 13 hydroxybenzoic acid manufacturers and their company rankings. Here are the top-ranked hydroxybenzoic acid companies as of December, 2024: 1.Green Chemicals Co., Ltd., 2.LCP Leuna Carboxylation Plant GmbH, 3.FabriChem.
Table of Contents
Hydroxybenzoic acid is a compound in which a hydrogen in the phenyl group of benzoic acid (Ph-COOH) is replaced by a hydroxy group.
It is represented by the chemical formula C7H6O3 and has a molecular weight of 138.12. There are three isomers according to the position of the hydroxy group: 2-hydroxybenzoic acid (o-hydroxybenzoic acid), 3-hydroxybenzoic acid (m-hydroxybenzoic acid), and 4-hydroxybenzoic acid (p-hydroxybenzoic acid).
In particular, 2-hydroxybenzoic acid has anti-inflammatory and analgesic effects and is known by the common name "salicylic acid"; CAS registration numbers are 69-72-7 for salicylic acid (2-hydroxybenzoic acid), 99-06-9 for 3-hydroxybenzoic acid, 99-96-7 for 4-hydroxybenzoic acid, 96-7.
Among hydroxybenzoic acids, salicylic acid (2-hydroxybenzoic Acid) is a drug approved for use in skin diseases because of its anti-inflammatory, analgesic, and skin softening properties. Dosage forms include adhesive plasters, ointments, and liquids. The main indication as an adhesive plaster is exfoliation of verrucae, chicken eyes, and callosities. Indications for ointments and liquids include psoriasis, tinea, keratosis, eczema with keratosis, atopic dermatitis, and contusions.
Otherwise, the substance is sometimes used as a raw material for organic synthesis. 4-hydroxybenzoic acid is also an intermediate in ubiquinone synthesis and other processes in vivo, and is found in a wide range of organisms, including animals, plants, and microorganisms. Salicylic acid is also a substance widely found in plants. Against this background, it is sometimes used in research and development as a reagent for culture engineering, plant tissue culture, plant growth control reagents, and growth inhibitors.
Salicylic acid has a melting point of 159°C and a boiling point of 211°C. It is a colorless needle-like crystal at room temperature. It has a density of 1.443 g/cm3 and an acid dissociation constant pKa of 2.97. It is soluble in ethanol, ether, and acetone, and insoluble in water.
The method for synthesizing salicylic acid is known as the Kolbe-Schmidt reaction. In this reaction, carbon dioxide is applied to an alkali metal phenoxide at high temperature and pressure to carboxylate the ortho-position, and salicylic acid is obtained after neutralization with acid.
3-hydroxybenzoic acid has a melting point of 201-205°C and is a white to pale yellow crystalline powder or powder at room temperature. It is soluble in ethanol, acetone, ether, and hot water and insoluble in cold water. 3-hydroxybenzoic acid is synthesized from 3-chlorobenzoic acid in pseudomonas sp.
4-hydroxybenzoic acid has a melting point of 214-217°C and is a white to almost white crystalline powder or powder at room temperature. Its density is 1.443 g/cm3. It is readily soluble in ethanol and acetone, but insoluble in water and chloroform.
Industrially, 4-hydroxybenzoic acid is produced from potassium phenoxide and carbon dioxide. In the laboratory process, potassium salicylate and potassium carbonate are heated to 230°C and treated with acid after the reaction.
The ester of 4-hydroxybenzoic acid is also called paraben and is a substance used as a preservative.
Hydroxybenzoic acid has three positional isomers, as mentioned above. All are commercialized and sold as reagents for research and development, and are available in easy-to-handle laboratory volumes such as 25 g, 100 g, and 500 g .
Of the three isomers, salicylic acid is a pharmaceutical product approved and marketed as a skin disease agent. Salicylic acid, other products include 10% salicylic acid ointment and liquid, and salicylic acid-containing adhesive bandages. Various manufacturers offer products for this drug.
*Including some distributors, etc.
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FabriChem, founded in Milford, Connecticut, in 1993 is a supplier of chemical ingredients for raw material sourcing and custom contract manufacturing. The company's product portfolio includes Specialty & Fine Chemicals, Pharmaceutical Ingredients, Biochemicals, Diagnostics & Buffers and Cosmetic & Oral Care Ingredients. The company serves markets such as research centers, testing and diagnostic labs, healthcare and educational institutions. They also provide services such as Product Selection Guidance, quality control and Custom Manufacturing.
Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
Shri Rajaram Chemicals & Engg, founded in Pune, Maharashtra, in 2011 is a manufacturer and supplier of Pharmaceutical Chemicals, Fine Chemicals, Laboratory Chemicals & Agricultural Goods. The company's product portfolio includes Fresh Ginger, Dry Ginger Dimethyl Isosorbide, Anthrone, Thiomalic Acid and N-(1-Naphthyl)-Ethylenediamine Dihydrochloride. Their products are used in industries such as Food and Beverage, Pharmaceutical and Biotechnology, Chemical and Petrochemical, Environmental Testing and healthcare. They export to Europe, America, Africa, the Middle East and Australia.
Emco Dyestuff Pvt. Ltd., established in 1980 with headquarters in India, is a manufacturer of intermediates, industrial chemicals, solvents, and specialty chemicals used in various industries, including agrochemicals, electronics, and pharmaceuticals. Some of the company's products are ethylhexanoic acid, sodium sulfate anhydrous, Toluene Diisocyanate, and monoethylamine. The company is partnered with a number of companies, including OpenSpace Services, a manufacturer of specialty chemicals; Emco Engineering, a manufacturer of pharmaceutical machines; and Kosha Chemtech Pvt. Ltd., a software and IT support company providing simplified outsourcing solutions.
Forbes Pharmaceuticals was founded in 1980 and is headquartered in Maharashtra, India. The company is a manufacturer, trader, supplier, and exporter of a wide assortment of specialty chemicals that are used in a diverse range of industries. The company conducts research and development in-house to continually increase product offerings at a lower cost to consumers. The company’s product categories include various organic and inorganic compounds as well as chemical supplies including sulfates, nitrates, nitrites, carbonates, and oxides.
Sisco Research Laboratories Pvt. Ltd., established in 1975, is an Indian manufacturer and supplier of chemicals, biochemicals, and reagents, headquartered in Mumbai, Maharashtra. Supported by Food and Drug Administration (FDA)-approved manufacturing facilities, the company offers a range of products, including general laboratory chemicals and solvents, biochemical, bioreagents, and specialty fine chemicals. Their offerings also include animal cell culture, BioLit™ range of DNA and protein tools, and nanotechnology products. Additionally, SRL provides dehydrated culture media, biological ingredients, media supplements, chromogenic media, and media kits. These products serve diverse industries such as biotechnology, confectionary and food, personal care products, pharmaceuticals, and protein purification.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
BioCrick Co., Ltd is located in Chengdu Tianfu Life Science Park in Sichuan Province, China. The company creates a natural product library which provides small molecular compounds with potential biological and pharmacological activities for pharmaceutical, agricultural, and biotechnology companies worldwide. The company’s database includes more than 8,000 compounds collected from natural sources such as as medicinal plants, herbs, fungus, and microbes. The company also a provider of peptides and lab reagents for biological research, carrying a product line in apoptosis, epigenetic, and cancer biology.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
National Analytical Corporation (NAC) is located in Mumbai, India. NAC was founded in 2009 as a distributor of laboratory grade chemicals used in numerous industries. NAC’s chemical offerings include biochemical & reagents such s Prunetin and 1,2-dipalmitoly-rac-glycerol, analytical grade chemicals such as chicoric acid and Vitamin E solutions, laboratory chemicals such as formic acid and nitric acid, gas chromatography chemicals such as Aalborg mass flowmeter battery kits and DEX 225, reference standard chemicals such as Palladium in HNO3, oral solid dosage forms, such as cellulosic and protect film coating systems, parenteral dosage forms, beverage & nutrition, and coating chemicals.
Glentham Life Sciences is based in Corsham, United Kingdom. Glentham Life Sciences is a leading supplier of fine chemicals, raw materials, reagents, and life science products. Glenthem also offers a number of services including custom packaging, call-off orders, and safety documentation. Glentham’s product offerings include chemicals such as amino acids, antibiotics, APIs, biochemicals, buffers, carbohydrates, chitin, chitosan, detergents, dyes, stains, enzymes, inorganic, peptide reagents, phytochemical, raw materials, solvents, steroids, and vitamins among others.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Green Chemicals Co., Ltd. |
42.9%
|
| 2 | LCP Leuna Carboxylation Plant GmbH |
14.3%
|
| 3 | FabriChem |
14.3%
|
| 4 | Shri Rajaram Chemicals & Engg |
14.3%
|
| 5 | Parchem |
14.3%
|
Derivation Method
The ranking is calculated based on the click share within the hydroxybenzoic acid page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
7 | 58.3% |
|
United States of America
|
2 | 16.7% |
Germany
|
1 | 8.3% |
Japan
|
1 | 8.3% |
|
United Kingdom
|
1 | 8.3% |
