This section provides an overview for arsenic acid as well as their applications and principles. Also, please take a look at the list of 7 arsenic acid manufacturers and their company rankings. Here are the top-ranked arsenic acid companies as of November, 2024: 1.Parchem, 2.Redox, 3.Santa Cruz Biotechnology, Inc..
Table of Contents
Arsenic acid is an inorganic compound that is an oxoacid of arsenic.
It has the chemical formula H3AsO4 and is also known as orthoarsenic acid.
The formula is 141.943, the melting point is 35.5℃ (1/2 hydrate), the melting point is 160℃, and it is colorless crystal (1/2 hydrate) at room temperature. It is soluble in water with a density of 2.5 gcm-3 and a solubility in water of 96.2 g/100 g (at 20°C). Its acid dissociation constants, pKa, are 2.24, 6.96, and 11.50.
Arsenic acid and arsenate are designated as nonmedicinal toxicants.
Arsenic acid is mainly used as an insecticide, rat poison, in the organic dye industry, and as a raw material for organic and inorganic arsenic preparations. In particular, arsenic acid has been used as an insecticide for termite control. However, due to its high toxicity, environmental pollution, and health hazards, it is currently not allowed to be used in Japan.
Arsenic acid has been isolated as a colorless crystal of 1/2 hydrate, which is hygroscopic and extremely soluble in water. Because of its high tidal solubility, it is often used in aqueous solution or hydrate form, or as arsenic acid.
Arsenic acid anhydride and 0.5 hydrate are hygroscopic and easily deliquescent. The anhydride crystals are said to be slightly endothermically soluble in water. In arsenic acid, the oxidation number of the arsenic atom is +V (+5), the highest oxidation state, and the substance exhibits the properties of a trivalent acid.
In this respect, it is similar to phosphoric acid. Since it is tidally soluble and soluble in water, it is important to keep it tightly sealed during storage.
An aqueous solution of arsenic acid is a weak acid that undergoes three stages of electrolysis. First-step ionization produces dihydrogen arsenate (H2AsO4-), second-step dissociation produces hydrogen arsenate (HAsO42-), and third-step dissociation produces arsenic acid ion (AsO43-). The arsenic acid ion has a tetrahedral structure, similar to that of phosphate.
The first stage of electrolysis dissociates rather strongly, with an ionization degree of about 0.25 in a 0.1 mol dm-3 aqueous solution; the second and subsequent stages decrease sequentially, and the dissociation in acidic solutions is considered negligible.
Arsenic acid itself is highly deliquescent and difficult to handle, so it is basically not sold as a product in anhydrous form. It is sold as arsenic acid solution at a concentration of about 60%, and in solid form as salt. Basically, it is sold as a chemical for research and development and industrial use.
The most common arsenic acid salt is disodium hydrogen arsenate heptahydrate (Na2HAsO4-7H2O). This substance is a white crystal or crystalline powder at room temperature, soluble in water and virtually insoluble in ethanol. It is handled as a reagent product that can be stored at room temperature and has applications, such as a detection reagent for alkaloids.
Arsenic acid is produced by the oxidation of simple arsenic or diarsenic trioxide with concentrated nitric acid. When this solution is concentrated, fine plate-like crystals of 0.5 hydrate precipitate below 29.5°C, and above 29.5°C, arsenic trioxide (H5As3O10) precipitates.
Another method is obtained by dissolving diarsenic pentaoxide in water.
Aqueous solutions of arsenic acid exhibit weak oxidative activity, e.g., oxidizing iodide ions to iodine. Arsenic acid is also a substance that is desorbed by gentle heating. Triarsenic acid (H5As3O10) is formed, and further heating yields diarsenic pentaoxide from 250 °C, but complete dehydration requires temperatures above 500 °C.
Diarsenic acid (H4As2O7) or polyarsenic acid (Hn+2AsnO3n+1, (HAsO3)n) and its ions are unstable in aqueous solution and are quickly hydrolyzed to form arsenic acid or arsenate ion.
*Including some distributors, etc.
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Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
Redox is an Australian distributor of chemical ingredients and raw materials founded in 1965 and based in Sydney. The company’s product inventory includes various coatings and resins, acids, preservatives, and water treatment chemicals. It also offers services such as developing and blending custom formulations, repacking, and warehousing for large custom orders. Redox supplies client manufacturers in a wide range of industries including textiles, pharmaceuticals, household consumer products, and agriculture. The company maintains multiple sales offices in Australia, the US, New Zealand, and Malaysia.
Ranking as of November 2024
Derivation MethodRank | Company | Click Share |
---|---|---|
1 | Parchem |
50.0%
|
2 | Redox |
37.5%
|
3 | Santa Cruz Biotechnology, Inc. |
12.5%
|
Derivation Method
The ranking is calculated based on the click share within the arsenic acid page as of November 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
Country | Number of Companies | Share (%) |
---|---|---|
United States of America | 2 | 33.3% |
Japan | 2 | 33.3% |
United Kingdom | 1 | 16.7% |
Australia | 1 | 16.7% |