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This section provides an overview for alpha lipoic acids as well as their applications and principles. Also, please take a look at the list of 39 alpha lipoic acid manufacturers and their company rankings. Here are the top-ranked alpha lipoic acid companies as of December, 2024: 1.Natrol, LLC., 2.Reflex Nutrition, 3.ChemScence.
Table of Contents
Alpha lipoic acid (ALA), chemically known as C8H14O2S2, is a potent antioxidant and an essential cofactor for enzymatic activities. Distinguished by its capability to enhance mitochondrial thermal energy production and promote metabolism, ALA surpasses the antioxidant power of vitamin C by 400 times. Its benefits extend to promoting sugar metabolism and heavy metal excretion.
As a versatile pharmaceutical ingredient and dietary supplement, ALA supports liver function, and brain metabolism, and can be found in foods like carrots, tomatoes, and spinach. Its pharmaceutical use includes dosages of 10-60 mg for adults to improve liver dysfunction and influence brain metabolism.
ALA is characterized by its melting point of 59-62°C and solubility in ethanol. Research indicates its potential to improve insulin resistance, LDL cholesterol, and fasting blood glucose levels, alongside slight decreases in body weight and BMI. However, its use in diabetic patients requires caution due to the risk of hypoglycemia.
Derived from octanoic acid, ALA features a cyclic disulfide bond and exists as two mirror isomers, (R)-ALA and (S)-ALA. The biologically significant form is (R)-ALA, highlighting the importance of optical activity in its efficacy.
The industrial availability of (R)-ALA and (S)-ALA with high optical purity marks significant progress from the racemic forms used in the mid-20th century. Today, China leads in ALA production, with contributions also from Italy, Germany, and Japan.
In aerobic metabolism, ALA acts as a cofactor for the pyruvate dehydrogenase complex, among others, facilitating the transport of acyl groups and aiding in the citric acid cycle.
ALA transitions between its oxidized form, β-ALA, and its reduced form, dihydrolipoic acid, which is essential for its biochemical activity, emphasizing the dynamic nature of its function in the body.
*Including some distributors, etc.
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ChemScence, LLC., established in 2006, is an American manufacturer based in Monmouth Junction, New Jersey, specializing in building blocks and fine research chemicals. The company offers approximately 45,000 building blocks and intermediates, as well as thin layer chromatography, screening libraries, bioactive small molecules, and isotope compounds. ChemScence also provides dye and biochemical assay reagents, peptides, and natural products like glycosides, and steroids. Catering to a diverse clientele including universities, research institutions, as well as pharmaceutical and biotechnology companies, ChemScence extends its services to include custom chemistry solutions. Furthermore, the company offers technical expertise in the domain of new drug development.
MedKoo Biosciences, Inc. is an American manufacturer of biochemical reagents established in 2009 and based in Morrisville, North Carolina. Specializing in small molecule drugs for laboratory use, the company offers a wide range of products including apoptosis inducers, anticancer reagents, epigenetic modulators, and various pharmaceutical related chemicals. These have applications in various fields including microbiology, stem cell research, endocrinology, and epigenetics. MedKoo Biosciences also provides R&D services to client biotechnology, biomedical, and pharmaceutical companies, as well as academic institutions.
Cayman Chemical Company is a manufacturer of life science research products founded in 1979 in Ann Arbor, Michigan, USA. They offer a diverse array of analytical standards, reagents, and other products for research in cancer, oxidative injury, epigenetics, neuroscience, inflammation, as well as metabolism, and other areas. The company supplies small molecules, biochemicals, assay kits, antibodies, and proteins to research scientists across academic, biotechnology, and pharmaceutical institutions. Cayman Chemical Company holds dual accreditations to ISO/IEC 17025:2017 and ISO 17034:2016 by ANAB Accreditation Services.
Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
MedChemExpress (MCE), is headquartered in Monmouth Junction, New Jersey, and is a supplier of research chemicals and biochemicals for laboratory and scientific use. The company’s product range includes biochemical assay reagents, isotope-labeled compounds, inhibitory antibodies, recombinant proteins, and fluorescent dyes. These products are used in various biopharmaceutical research and development fields, including areas such as infection, cardiovascular diseases, neurodegenerative diseases, diabetes, and autoimmune diseases. The company is ISO 19001 certified and provides testing services within the ISO 17025 framework, offering bulk and custom product services and support for metrological traceability.
Ambeed, established in 2015 and headquartered in Arlington Heights, Illinois, is a manufacturer and supplier of catalog products, including inhibitors, natural products, nucleotides, building blocks, and amino acids. The company mainly specializes in organoboron, metal catalysts, heterocyclic building blocks, and materials science-related products. Its catalog has more than 100,000 in-stock products, increasing monthly. As of 2019, the company’s R&D center had developed five product lines with over 600,000 products. The company provides pre-sale and after-sale services and works with distributors from several countries, including India, Pakistan, Egypt, Poland, and Brazil.
United States Biological, located in Salem, Massachusetts, is a manufacturer and supplier of life science research products. Its product offerings include biochemicals, antibodies, and molecular biology kits. The company’s products are used in various fields such as genomic research, biotechnology, and pharmaceutical development. Products are available from affordable research quantities to larger bulk amounts for process development and production. Its customer base comprises pharmaceutical and biotechnology companies both in the US and overseas.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
GlpBio Technology, established in 2016 and headquartered in Montclair, California, is a supplier of life science products covering 20 popular research fields, including epigenetics, neuroscience, and cancer. Its product portfolio has over 20,000 life science reagents, including biochemicals, tag peptides, bioactive peptides, amino acids, and nature products. Its main clients include clinical diagnostic laboratories, government agencies, research institutes, universities, and pharmaceutical companies. The company regularly increases its products to meet the latest research needs and provides custom organic synthesis and analytical services.
Life Extension Foundation is a company that sells dietary supplements, vitamins, and other health products. It is headquartered in Fort Lauderdale, Florida, and was founded in 1981. The company offers a wide array of dietary supplements, vitamins, minerals, and herbal extracts. Its products, such as vitamins, moisturizers, and functional foods are science-backed and help target different health concerns, including weight gain, signs of skin aging, and digestive issues. Life Extension also offers multiple services, such as health information, online doctor consultations, and lab testing. The company's products are available through its website, mail order, and retail stores.
Source Naturals, Inc., founded in the United States, is a supplier of nutritional supplements. The company offers a wide selection of nutritional supplements, including vitamins, minerals, herbal supplements, protein powders, and more. The company evaluates the underlying causes of system imbalances and then provides targeted nutrition to interdependent body systems. It has a line of more than 600 products including well-researched, single-entity nutrients, and also provides expert advice on product selection and usage.
FujiFilm Wako Pure Chemical Corporation, founded in 1922 and headquartered in Osaka, Japan, is a manufacturer of laboratory chemicals, specialty chemicals, and clinical diagnostic reagents. The company has three business domains, namely laboratory chemicals, specialty chemicals, and clinical diagnostic reagents, and some of its products include biochemistry reagents, blood transfusion test drugs, battery materials, polymer-related materials, and general reagents. The products are useful in various fields, including electronic, cosmetic, polymeric, pharmaceutical, and medical care. It acquired Sibayagi Co. Ltd. in 2015 and provides custom manufacturing to meet customer requirements.
Wuhan Fortuna Chemical Co., Ltd., established in 2006 and headquartered in Wuhan, China, is a manufacturer that engaged in organic and fine chemical products, laboratory chemicals, and chemical wholesale products. The company offers a range of products, including flunixin meglumine, amitraz, sodium hyaluronate, carprofen, and cottonseed oil. It also provides custom-tailored products according to client's requirements. Its Antioxidant 245 has low volatility, which means it does not evaporate easily. The company has achieved ISO9001 and GMP certification. Its products are exported to South Korea, Vietnam, Australia, Europe, and South America.
LGC Standards Ltd., established in 1842, is a global British manufacturer and supplier of reference standards, headquartered in Teddington, Middlesex, with offices in 20 countries worldwide. As a subsidiary of LGC Group, the United Kingdom’s National Measurement Institute, LGC Standards also serves as the Government Chemist, providing expert opinions based on independent chemical and bioanalytical measurements. Under the business unit LGC Industrial, the company offers industrial measurement tools. Additionally, their subsidiaries, including Toronto Research Chemicals Inc (TRC) of Canada, LGC Mikromol™, and Dr. Ehrenstorfer™ of Germany, develop research tools, standards for pharmaceutical quality control, and reference materials for food and environmental analysis.
Biosynth is a Swiss manufacturer of life science reagents established in 1966 and headquartered in Staad. The company sources and manufactures biochemical products such as carbohydrates, nucleosides, and enzyme substrates, as well as various peptides and biologics. They also operate as a contract manufacturer offering custom synthesis and manufacturing services for their clients in the pharmaceutical, diagnostic, food, and agrochemical sectors. Biosynth has regional sales offices and specialized facilities in Europe and North America, including in the Netherlands, United Kingdom, and United States.
Alfa Chemistry, founded in the year 2015 is based in New York, USA as a biotechnology company and manufacturer of graphene materials. Their product portfolio includes graphene oxide, CVD graphene film, graphene modification services, graphene series, graphene-like material, carbon nanomaterials, quantum dots, upcoming nanoparticles, and graphene transfer services. The company also provides services in custom manufacturing, and graphene analysis with quality assurance. The products are used in various industries which include energy, digital electronics, environment, textile, coating, and biomedical science.
Sincere Chemical, established in 2001 and located in Shijiazhuang City, China, is a manufacturer that specializes in the production and sales of pharmaceutical intermediates. The company's main products include glacial acetic acid, hydrochloric acid, ammonium hydroxide, nitric acid, and sodium hypochlorite. It also offers customized products such as custom-designed wood boxes, custom mini oak barrels for packaging, and custom-burned logo camping wood boxes. It offers preponderant pricing for its products, making it an affordable option for customers. It serves various industries, including the chemical, paint and coating, agriculture, and manufacturing industries.
Jinan Qinmu Fine Chemical Co., Ltd., established in 2008, is a Chinese manufacturer of chemical products, headquartered in Jinan, Shandong. The company offers organic and inorganic chemicals, including solvent chemicals, catalysts, and auxiliaries. Additionally, the company provides dye and pigment chemicals, pharmaceutical and synthetic intermediates, active pharmaceutical ingredients (APIs), and biochemical products. Customized intermediates are also available to meet the specific needs of original equipment manufacturers (OEMs). As an ISO 9001 and ISO 14001 certified company, Qinmu Fine Chemical Co., Ltd. serves a global customer base, including clients like Miwon Specialty Chemical Co., Ltd., Synthos S. A., and Gujarat Fluorochemicals Limited (GFL).
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
Capot Chemical Co.,Ltd was established in 1996 and is a manufacturer of custom synthesis products based in Hanghzhou, P.R. China. The company manufactures various organics products such as boronic acids, unnatural amino acids, cross linkers, chiral building blocks, and heterocyclic compounds. The management of the company have obtained the ISO 9001:2015 standards certification for the safety management system. The company have participated in various exhibitions, such as Chemspec Europe in Basel and CPhI in Barcelona, Shanghai, Milan, and Philadelphia.
Hubei Sanxin Biotechnology Co., Ltd. was established in March 2011, located in Dongcheng Industrial Park, Fang County, and is a manufacturer of health ingredients. The agricultural enterprise in Shiyan City owns a GMP planting base with more than 4942 acres and two automatic production lines, producing over 800 tons of plant extracts annually. The company has passed FDA certification and Kosher certification, with main products featuring polygonum cuspidatum extracts, pueraria extracts, macleaya cordata extracts, baicalin, Coenzyme Q10, and sodium copper chlorophyllin. The extracts are used in food, health care products, medicines, cosmetics, veterinary medicine, and many other fields.
Shaanxi Hongda Phytochemistry Co., Ltd., established in 2001 and based in Sanyuan, Shaanxi, China, is a manufacturer of natural plant extract ingredients. The products made by the company, such as natural herbal extracts, API, a natural carotenoid, and veterinary raw materials, are supplied to different industries, such as nutraceuticals, pharmaceuticals, healthcare, and cosmetics. The company products are made in the SGC-certified laboratory and hold different certifications such as BRC, Kosher, Halal, ISO9001, ISO22000, Organic, SC, and FDA registered.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
BLDpharm was founded in 2014 and headquartered in Shanghai, China is a manufacturer and supplier of various research chemicals. The company offers a wide range of laboratory chemicals including heterocycles, boron acids, amino acids, metal catalysts, and chiral compounds. These quality products find an array of applications as inhibitors for metabolic enzymes, pharmaceutical intermediates for antipsychotic drugs, catalysts for chiral resolving reagents, and material science for OLED material and synthesis intermediates.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Zhejiang Panadu Machinery Technology Co., Ltd., established in 2007 and based in Taizhou, Zhejiang, China, is a manufacturer and distributor of fixed-torque tools. The company's product lineup includes electric torque wrenches, pneumatic torque wrenches, cordless torque wrenches, manual torque wrenches, and sleeves. These tools are used for installation and maintenance across various sectors. It serves industries such as railways, petrochemicals, electric power, metallurgy, and the military. The company also offers services such as product development, quality assurance, user consultations, and bolt and nut disassembly and assembly programs.
Avanscure Lifesciences Private Limited, established in 2012 and based in Gurugram, Haryana, India is a manufacturer of active pharmaceutical ingredients. The company manufactures pharmaceutical nutraceuticals, vitamins, food additives, amino acids, and anti-cancer drugs. It is located in the industrial areas of Gurugram and doubles up as a supplier and trader of industrial and laboratory chemicals. It caters to the health and wellness industry, with a special importance on oncology, hormones and peptides. The company has a modern chemical processing unit, where superior technology is used to process chemicals like Amiodarone, Hydrochloride, Acetazolamide, and Bethanechol chloride.
Shanghai Theorem Chemical Technology Co., Ltd., established in 1997, is a company located in Shanghai, China, is a manufacturing company specializing in researching and manufacturing chemical new materials and fine chemicals. The company offers new functional materials, surfactants, polyurethane chemicals, special isocyanates, extractants, and more. They have a product chain advantage and offer professional technical support, and stable production supply with authorized ISO9001 quality management system, ISO14001 environmental management system, as well as related certifications. Their manufacturing factory with a land area of 80,000 m2, has over 300 workers, 30 engineers, 7 production workshops.
Glentham Life Sciences is based in Corsham, United Kingdom. Glentham Life Sciences is a leading supplier of fine chemicals, raw materials, reagents, and life science products. Glenthem also offers a number of services including custom packaging, call-off orders, and safety documentation. Glentham’s product offerings include chemicals such as amino acids, antibiotics, APIs, biochemicals, buffers, carbohydrates, chitin, chitosan, detergents, dyes, stains, enzymes, inorganic, peptide reagents, phytochemical, raw materials, solvents, steroids, and vitamins among others.
ChemSrc, established in 2014, is a supplier of pharmaceutical products, a chemical database platform, and a search engine. This platform serves as a gateway to an extensive repository of chemical knowledge, offering access to unique CAS-encoded product records including synthesis routes, literature references, physical and chemical properties, and supplier information. The chemical catalog spans various categories, including organic raw materials, dyes and pigments, chemical pesticides, catalysts, additives, and more. The repository information plays a vital role in supporting research and development efforts across diverse industries by fostering scientific advancements and serving as a valuable resource.
AbMole BioScience, headquartered in Houston, Texas, USA, is a supplier of high-purity life science reagents. The company specializes in kinase inhibitors tailored for laboratory research. Its extensive product range also encompasses of recombinant proteins, organoid molecules, fluorescent dyes, and compound libraries, catering to a diverse spectrum of life science research areas. It holds a collection of over 8,000 inhibitors targeting a range of key proteins such as HDAC, PI3K, and apoptosis regulators.
Tocris Bioscience, trading as Tocris Cookson Ltd., established in 1982 and headquartered in Bristol, UK, is a supplier of life science reagents. Its extensive product range encompasses receptor agonists and antagonists, enzyme inhibitors, ion channel modulators, fluorescent probes and dyes, along with PROTAC Degraders for targeted protein degradation. The compay has received several accolades, including The Queen's Awards for Enterprise in International Trade. The company is part of the life science division of Bio-Techne, which also includes class brands R&D Systems, Novus Biologicals, ProteinSimple and Advanced Cell Diagnostics.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Natrol, LLC. |
9.4%
|
| 2 | Reflex Nutrition |
9.4%
|
| 3 | ChemScence |
9.4%
|
| 4 | Hubei Sanxin Biotechnology Co., Ltd. |
6.3%
|
| 5 | SHANDONG SINCERE CHEMICAL CO., LTD. |
6.3%
|
| 6 | MedKoo Biosciences, Inc. |
6.3%
|
| 7 | Shanghai Theorem Chemical Technology Co., Ltd. |
6.3%
|
| 8 | Life Extension Foundation |
6.3%
|
| 9 | Hangzhou Fanda Chemical Co.,Ltd. |
3.1%
|
| 10 | Shaanxi Hongda Phytochemistry Co., Ltd. |
3.1%
|
Derivation Method
The ranking is calculated based on the click share within the alpha lipoic acid page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
13 | 43.3% |
|
China
|
9 | 30.0% |
|
United Kingdom
|
3 | 10.0% |
|
Japan
|
2 | 6.7% |
|
Switzerland
|
1 | 3.3% |
| United States | 1 | 3.3% |
|
Canada
|
1 | 3.3% |
