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This section provides an overview for salicylamide as well as their applications and principles. Also, please take a look at the list of 14 salicylamide manufacturers and their company rankings. Here are the top-ranked salicylamide companies as of December, 2024: 1.Alpha Chemica, 2.SimSon Pharma Limited, 3.Rishabh Metals and Chemical Pvt. Ltd..
Table of Contents
Salicylamide is a white crystalline or crystalline powder aromatic compound. Its IUPAC name is 2-hydroxybenzamide, and it is also known as o-hydroxybenzamide.
Its chemical formula is C7H7NO2 and its molecular weight is 137.14. The CAS registration number is 65-45-2.
Salicylamide is obtained by amidation of methyl salicylate with ammonia in a nucleophilic substitution reaction.
Salicylamide is a non-steroidal anti-inflammatory drug that reduces fever, swelling, and pain. Its antipyretic and analgesic effects are similar to those of aspirin.
It has been used in many over the counter drugs as an orally administered nonsteroidal anti-inflammatory drug, but is rarely used today.
Non-steroidal anti-inflammatory drugs inhibit the production of substances (prostaglandins) produced by the body that cause pain, fever, and inflammation. The inhibitory effect of prostaglandin production can relieve pain and reduce inflammation, but it cannot cure the cause of the pain, fever, or swelling itself.
Salicylamide is a solid at room temperature with a melting point of 140-144°C and a boiling point of 270°C. It is very soluble in N,N-dimethylformamide, soluble in ethanol, propylene glycol and sodium hydroxide solution, and slightly soluble in diethyl ether and dimethyl sulfoxide. It is not very soluble in water or chloroform.
It has a pH of 5, which indicates the degree of acidity or alkalinity, and an acid dissociation constant (pKa) of 8.37. The acid dissociation constant is a quantitative indicator of the strength of an acid; the smaller the pKa, the stronger the acid.
The following side effects have been reported with salicylamide:
Avoid use in children with influenza, aspirin asthmatics, and patients with peptic ulcer.
Handling precautions
Avoid contact with strong oxidizers. Use in a draft chamber with local exhaust ventilation. Wear personal protective equipment when using.
In case of fire
When burning, carbon monoxide, carbon dioxide, nitrogen oxides, etc. are produced. Use water spray, foam, powder extinguisher, carbon dioxide, extinguishing sand, etc. to extinguish fire.
In case of skin contact
Be careful not to get it on skin. Always wear protective clothing such as a lab coat or work clothes and protective gloves when using the product. Never roll up the sleeves of protective clothing to avoid skin exposure.
In the event of skin contact, wash off with soap and plenty of water. If on clothing, remove all contaminated clothing and isolate. If symptoms persist, seek medical attention.
In case of eye contact
Always wear protective glasses or goggles when using the product. In the unlikely event of eye contact, rinse carefully with water for several minutes. If you are wearing contacts and can easily remove them, take them off and rinse thoroughly. Seek immediate medical attention.
Storage
Salicylamide may be altered by light. When storing, place in a light-shielded glass container and keep tightly closed. Store locked up in a well-ventilated, cool place as far as possible, away from high temperatures and direct sunlight.
*Including some distributors, etc.
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Molekula Group, established in 2000, is a chemical manufacturer and distributor based in Darlington, United Kingdom, supported by additional offices and warehouses in Germany, Italy, China, and the United States. The company operates two British subsidiaries, namely Scafell Organics Ltd, which manufactures fine organic chemicals, and Sherman Chemicals Ltd, which provides custom solutions across industries. The company adheres to ISO 9001:2015 standards and offers a diverse range of over 4,500 products. Their product portfolio includes analytical reagents, biochemicals, building blocks, organic and inorganic chemicals, as well as research organics and inorganics.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Rishabh Metals and Chemical Pvt. Ltd. was founded in 1984 and is an ISO 9000 certified manufacturer of specialty chemicals based in Church Gate, Mumbai, India. The company manufactures various products such as salicylic acid, acryl amide, formulated polymers, online charge analyzers, and zeta potential analyzers. These products find applications across various industries, including waste water, mining, oil, ceramic, and industrial water. The company also offers wet end surveys for paper mills and manpower outsourcing for customers.
ALPHA CHEMICA, established in 1985, is an Indian manufacturer and supplier of laboratory reagents and fine chemicals, headquartered in Mumbai, Maharashtra. Their wide range of products includes high-performance liquid chromatography (HPLC), analytical reagent/guaranteed reagent (AR/GR), laboratory reagents (LRs), and fine chemicals, catering to life science and other specialty research. During the COVID-19 pandemic and its aftermath, ALPHA CHEMICA offered BactGO, a disinfectant solution with stabilized hydrogen peroxide using silver-based chemistry, and BaVi-X, a 75% alcohol-based hand sanitizer.
SimSon Pharma Limited, established in 2011 and headquartered in Mumbai, India, is a manufacturer and supplier of pharmaceutical reference materials. Their product range includes drug working standards, drug impurity standards, drug metabolites, and stable isotope labeled compounds. These provide a basis for comparison and validation, enabling pharmaceutical companies to produce safe and effective medications. The company's offerings serve specific purposes, such as calibrating analytical instruments and ensuring precise analytical results, identifying and quantifying impurities in drugs, understanding drug metabolism, and developing new drug therapies.
Alta Laboratories Ltd was established in 1946 and is a manufacturer of salicylic acid and aspirin products based in Mumbai, India. The company manufactures various pharmaceutical products such as salicylic acid pharma grade, sodium methyl paraben, propyl paraben, sodium salicylate, and aspirin. Quality management system of the company has complied with various guidelines including Good Manufacturing Practice (cGMP), ICH Q7, WHO guidelines, Good Laboratory Practice (GLP), and SHE (Safety, Health, and Environment) policy. The company has served different fields of industries such as veterinary, preservatives, personal care, intermediates, and fragrances.
FujiFilm Wako Pure Chemical Corporation, founded in 1922 and headquartered in Osaka, Japan, is a manufacturer of laboratory chemicals, specialty chemicals, and clinical diagnostic reagents. The company has three business domains, namely laboratory chemicals, specialty chemicals, and clinical diagnostic reagents, and some of its products include biochemistry reagents, blood transfusion test drugs, battery materials, polymer-related materials, and general reagents. The products are useful in various fields, including electronic, cosmetic, polymeric, pharmaceutical, and medical care. It acquired Sibayagi Co. Ltd. in 2015 and provides custom manufacturing to meet customer requirements.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Dubi Chem was founded in 1995 and is headquartered in the United Arab Emirates. The company is a marine chemical manufacturer based in Asia, serving marine, oilfield, water treatment, automotive, and shipping industries. The company’s product list includes hundreds of chemicals and finished products, ranging from wheel cleaners to skin care pastes to oil drilling chemicals. The company provides services such as inspections and cleaning specialists who provide dedicated tank cleanings preloading and post-delivery, logistics services, and private labeling options for OEMs and other manufacturers to self-label.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Jigs Chemical was established in 1998 and is based in India with global offices in the USA, UK, Canada, and Australia. Jigs Chemical is a manufacturer, distributor, and marketing & sales provider for organizations in India, specializing in chemicals and active pharmaceutical ingredients for pharmaceutical, agriculture, ceramics, metal treatment, and other industries. Jigs Chemical helps facilitate international customers to obtain chemicals from India, providing import and export assistance. Jigs Chemical’s product catalog includes over 40000 active pharmaceutical ingredients, commonly called APIs, their respective intermediates, and other chemicals.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Alpha Chemica |
21.7%
|
| 2 | SimSon Pharma Limited |
17.4%
|
| 3 | Rishabh Metals and Chemical Pvt. Ltd. |
8.7%
|
| 4 | Central Drug House |
8.7%
|
| 5 | Molekula Americas LLC |
8.7%
|
| 6 | Junsei Chemical Co.,Ltd. |
8.7%
|
| 7 | KANTO CHEMICAL CO.,INC. |
8.7%
|
| 8 | nacalai |
8.7%
|
| 9 | Jigs chemical |
4.3%
|
| 10 | DUBI CHEM MARINE INTERNATIOAL |
4.3%
|
Derivation Method
The ranking is calculated based on the click share within the salicylamide page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
6 | 54.5% |
|
Japan
|
4 | 36.4% |
|
United States of America
|
1 | 9.1% |
