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This section provides an overview for chondroitin sulfate as well as their applications and principles. Also, please take a look at the list of 13 chondroitin sulfate manufacturers and their company rankings. Here are the top-ranked chondroitin sulfate companies as of December, 2024: 1.Spectrum Chemical Mfg. Corp., 2.Jo Mar Laboratories, 3.HorseTech..
Table of Contents
Sodium chondroitin sulfate is the sodium salt of chondroitin sulfate, an acidic mucopolysaccharide found in the cartilage of whales and sharks.
Chondroitin sulfate usually exists as a proteoglycan (a complex of sugar and protein with a special structure) and is widely distributed in connective tissues such as cartilage and skin, and in all tissues including the brain. Due to its water retention and viscosity, it also acts as a cushioning material in joints.
Its salt, chondroitin sulfate is a substance used as a medical drug and an over-the-counter drug.
Sodium Chondroitin Sulfate is a substance used in pharmaceuticals, foods, cosmetics, etc.
In pharmaceutical applications, it is a drug that is sold as both a prescription drug and an over-the-counter drug. As an ethical drug, it is indicated for the treatment of lumbago, arthralgia, and periarthritis of the shoulder in the form of an injectable solution, and for the protection of the superficial layer of the cornea in the form of eye drops.
As an over the counter drug, it is indicated for the treatment of arthralgia and neuralgia in oral form, and is also used as eye drops to protect the surface layer of the cornea in the same way as ethical drugs.
In food applications, chondroitin sulfate is used as an emulsion stabilizer in the manufacturing process for mayonnaise, dressings, and other products. This is because chondroitin sulfate has excellent water absorption and water retention properties. It is also used in fish sausages to eliminate fish odor.
In cosmetic applications, it is used as a moisturizer due to its smooth feel.
Chondroitin sulfate has a structure in which a sulfate is attached to a repeating disaccharide chain consisting of D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc). Since there are variations in the position of the sulfate group and the presence or absence of GlcA epimerization in the repeating structure of this disaccharide unit, there are multiple isomers of chondroitin sulfate. Chondroitin sulfate sodium is a sulfate of each of these isomers.
In the monosaccharides that make up chondroitin sulfate sodium, the sulfate groups are mainly attached to the 4- and 6-positions of GalNAc. In chondroitin sulfate B (dermatan sulfate), GlcA of chondroitin sulfate is epimerized to form iduronic acid.
In chondroitin sulfate E, both positions 4 and 6 are sulfated, and in chondroitin sulfate D, the hydroxyl group of glucuronic acid is sulfated.
The types of chondroitin sulfate sold include reagent products for research and development, chemical products, and pharmaceuticals.
Reagent products for research and development include 0.1 g, 5 g, 25 g, and other capacities. In addition to those sold as chondroitin sulfate, isolated products of each of the aforementioned A~E types may also be sold.
In such cases, they are sold under product names such as Chondroitin Sulfate A Sodium, Chondroitin Sulfate B Sodium, Chondroitin Sulfate C Sodium, and Chondroitin Sulfate E Sodium, respectively. These reagent products are mainly used in the fields of cell biology and biochemistry, and are manufactured using chicken cartilage, porcine skin, squid cartilage, etc. as raw materials.
Note that products for research and development cannot be used for clinical purposes.
There are prescription drugs such as 200 mg injectable solution, 1%/3% eye drops, and various other over-the-counter drugs.
*Including some distributors, etc.
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Jo Mar Laboratories was established in 1979 and is a manufacturer and supplier of amino acid products base in Watsonville, California, United States. The company's products portofolio includes L-Asparagine, Glutathione, Chondroitin Sulfate, Creatine Monohydrate, and Glucosamine Sulfate. Various accessories and books related to amino acid products are also sold by the company. All of the products are manufactured with current Good Manufacturing Practices (cGMPs) under the standards provided by the FDA. The company provides discounts to professionals, doctors, and pharmacies, and also offers custom labeling.
HorseTech. was founded in 1999 and is a manufacturer of horses and dogs supplements based in Laurens, Iowa, United States. The company manufactures various equine and canine supplements such as joint support, vitamins, metabolic products, skin care, and digestive support supplements. Reitsport gears are also provided by the company to support customers who also participate in horse sports. Customers located in the contiguous 48 states of the United States are waived from shipping costs for every purchases. The company is an audited charter member of the National Animal Supplement Council (NASC).
Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
PureBulk was established in 2008 and is a distributor and supplier of dietary supplements based in Roseburg, Oregon, United States. The company sells various supplements products for different purposes, including vitamins, protein, sugar substitutes, gain muscle supplement, and weight loss medicines. The products are made in GMP compliant facility with Certificates of Analysis (COA) and MSDS information provided upon customer's request. The company provides free ground shipping to 48 states in the United States and offers various discounts to customers affiliated with military, responder, and education.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Seikagaku Corporation, established in 1947 and headquartered in Tokyo, Japan, is a manufacturer and supplier specializing in pharmaceuticals and medical devices related to glycoconjugates. The company’s product portfolio includes pharmaceuticals, and medical devices with applications spanning from understanding life processes, including aging, to pioneering unique drug discovery initiatives in glycoscience. The company has multiple facilities and locations across Japan and partners with companies in global markets to serve clients internationally. The company holds ISO 13485 certification and complies with the pharmaceutical laws and regulations of overseas countries.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Solabia Group was founded in 1972 and is a manufacturer of cosmetics and pharmaceuticals products based in Pantin, France. The company offers various products including antioxidant, nutricosmetics, stress management supplement, animal health analysis media, and body care treatments. The company publishes the Environmental, Social, and Governance (ESG) report annually and completing its Communication on Progress (CoP) on the United Nations Global Impact. Each year Solabia Group's actions are assessed by Carbon Disclosure Project (CDP) Climate and Water and Ecovadis platform, which awarded the company a Gold Sustainability rating in 2022.
Creative PEGWorks, headquartered in Chapel Hill, North Carolina, USA, has been a PEG reagents manufacturer and supplier since 2007. Its specialization is on PEGylation, polymer modification, custom synthesis of reactive polymers and oligomers, as well as particle surface functionalization. The company produces derivatives and reagents including polyethylene glycol, polysaccharide, and polyamino acid derivatives, catering to research needs at biotech and pharmaceutical companies, federal laboratories, and universities. Its consulting for drug delivery and formulation, protein modification, and nanoparticle surface modification as well as applications in pharma and biotech technologies and products are also available.
Iduron is a UK-based manufacturer and supplier specializing in Glycosaminoglycan products for the global heparin manufacturing industry and academic research and development. The company’s product portfolio includes Glycosaminoglycan degrading enzymes, Glycosaminoglycan disaccharide standards, heparin test kits, Glycosaminoglycan polymers, and Heparin Mw Polymer series. These products support the growing GAG-based scientific research sector. With worldwide shipping capabilities and key distributors in the USA and Japan, the company has a global reach and serves customers in diverse markets worldwide.
McKinley Resources Inc., founded in 2003 in the USA, is a manufacturer and supplier of skin care, hair care, over-the-counter active ingredients, walnut shells, and cosmetic specialty chemicals. It is providing solutions for a range of formulations, including products for anti-aging, anti-inflammation, anti-acne, anti-oxidant, and skin lightening, all backed by claim substantiation.The company offers an "OTC (Over-the-Counter) Active Ingredients" product line and Bionatrx Extract Powders for cosmetic, nutrition, health, and pharmaceutical applications. It also provides natural, and biodegradable walnut shells with short lead times for domestic and international customers.
Glentham Life Sciences is based in Corsham, United Kingdom. Glentham Life Sciences is a leading supplier of fine chemicals, raw materials, reagents, and life science products. Glenthem also offers a number of services including custom packaging, call-off orders, and safety documentation. Glentham’s product offerings include chemicals such as amino acids, antibiotics, APIs, biochemicals, buffers, carbohydrates, chitin, chitosan, detergents, dyes, stains, enzymes, inorganic, peptide reagents, phytochemical, raw materials, solvents, steroids, and vitamins among others.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Spectrum Chemical Mfg. Corp. |
15.5%
|
| 2 | Jo Mar Laboratories |
10.4%
|
| 3 | HorseTech. |
9.7%
|
| 4 | Glentham Life Sciences Limited |
9.7%
|
| 5 | PureBulk |
7.8%
|
| 6 | MilliporeSigma |
7.8%
|
| 7 | Solabia Group |
6.1%
|
| 8 | Santa Cruz Biotechnology, Inc. |
6.1%
|
| 9 | SEIKAGAKU CORPORATION |
5.8%
|
| 10 | Creative PEGWorks |
5.5%
|
Derivation Method
The ranking is calculated based on the click share within the chondroitin sulfate page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
5 | 55.6% |
|
Japan
|
2 | 22.2% |
|
United Kingdom
|
2 | 22.2% |
