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This section provides an overview for glucuronolactone as well as their applications and principles. Also, please take a look at the list of 13 glucuronolactone manufacturers and their company rankings. Here are the top-ranked glucuronolactone companies as of December, 2024: 1.Merck.
Table of Contents
Glucuronolactone is a white to light brown crystalline powder organic compound.
It is also known as D(+)-glucuronolactone, D-glucurono-3,6-lactone, glucurone, glucuronic acid lactone).
Glucuronolactone is not regulated by any of the major national laws and regulations.
Glucuronolactone is mainly used in the pharmaceutical field, where it is useful in medicines for liver diseases, drinks to relieve fatigue, and drugs for acne and skin problems. In the human body, glucuronolactone acts on the liver and helps the liver function.
Glucuronolactone is converted to glucuronic acid by water in the human body. In the liver, glucuronic acid combines with waste materials that are unnecessary for humans to form glucuronide conjugates. The formation of the complex facilitates the elimination of waste substances from the body. This mechanism has the effect of increasing the liver's detoxification capacity and blood flow.
In addition to improving the function of the liver, glucuronolactone also has an ameliorative effect on symptoms of hives, eczema, and pregnancy toxicity. These effects are not powerful, but they have few side effects.
The chemical formula is C6H8O and the molecular weight is 176.12. The CAS number is 32449-92-6.
Its melting point is 170°C and it is solid at room temperature. It is an odorless compound, easily soluble in water and virtually insoluble in ethanol and acetic acid.
When dissolved in water, it yields an aqueous solution in which both of the compatible isomers, glucuronolactone and glucuronic acid, are present. It has been reported that both compatible isomers are present in vivo.
Glucuronolactone is obtained by oxidation and hydrolysis of trehalose in the presence of a metal catalyst. Another method for producing glucuronolactone is reported, in which glucose is converted to glucuronic acid through microbial fermentation, followed by lactonization to produce glucuronolactone.
Handling Precautions
Avoid contact with strong oxidizing agents. It should be used in a draft chamber with local exhaust ventilation. Also, wear personal protective equipment when using.
In Case of Fire
Combustion decomposition may produce irritating and toxic gases and vapors. Use water spray, foam, powder extinguisher, carbon dioxide gas, or extinguishing sand to extinguish fires.
In Case of Skin Contact
Be careful not to get it on your skin. Always wear protective clothing such as a lab coat or work clothes and protective gloves when using the product. Never roll up the sleeves of protective clothing to avoid skin exposure.
In the event of skin contact, wash off with soap and plenty of water. If on clothing, remove all contaminated clothing and isolate. If symptoms persist, seek medical attention.
In Case of Eye Contact
Always wear protective glasses or goggles when using the product. In the unlikely event of eye contact, rinse cautiously with water for several minutes.
If wearing contacts, remove them if they can be easily removed and rinse thoroughly. Seek immediate medical attention.
Storage
When storing, place it in a glass container, sealed with an inert gas. Store locked up in a cool, well-ventilated place away from direct sunlight.
*Including some distributors, etc.
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Zouping Mingxing Chemical Co., Ltd., based in Shandong Province, China, and established in 2002, is a manufacturer of a wide array of essential products, including medical and pesticide intermediates, food additives, electronic flame retardants, and fine chemical raw materials. The company has an array of product portfolios, such as chemical auxiliaries, flame retardants, flavors and fragrances, food additives, pharmaceutical intermediates and more. The company has garnered a strong presence across 48 countries and regions, spanning the United States, Japan, South Korea, India, and Europe.
MUBY CHEMICALS, established in 1976, is a manufacturer and supplier of chemicals and excipients used in pharmaceuticals, cosmetics & personal care, agrochemical, and textile industries. Based in Ankleshwar, Gujarat, India, the company offers Shale gas hydraulic Fracturing Chemicals such as ammonium persulfate, diverting agents, inhibitors, ATMP phosphonate, and encapsulated gel breakers. Some food analytical reagent chemicals include benzyl alcohol, calcium oxide, boric acid, carbamide peroxide, and lithium carbonate. The company is GLP-approved, Kosher Certified, "REACH" Registered, and ISO-9001 Certified.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Fengchen Group Co., LTD is based in Qingdao, China. The company is a manufacturer and supplier of speciality chemicals for several industries around the world including natural resources, hydrogeology, drilling, geophysics, and environmental & geotechnical services. The company’s chemical product categories include APIs, amino acids, micronutrients, package materials, and enzymes. The company also offers services including specialized transportation, samples of compounds, shipping documents needed for pharmaceutical products, and international customs support.
Aadhunik Industries is a manufacturer and supplier of hydraulic fracturing chemicals, based in Mumbai, India. The company offer crystal granules in precise micron or mesh sizes according to buyers needs. These products are also available through its agents in the UAE and the USA. It also provides encapsulated gel breakers and low and high-temperature flow diverting agents for oil fracturing and drilling. The company and its associated units are FDA-GMP certified, Halal and Kosher certified, REACH registered, ISO-9001 certified, and ISO-22000 HACCP certified.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Samex Overseas, located in Gujrat, India,and established in 2002, is an exporter, manufacturer, and supplier of active pharmaceutical ingredients (API), bulk drug intermediates, and veterinary medicines, including IVERMECTIN EP. The company has a diverse product portfolio that includes corticosteroids, hormones and anabolic steroids, inhibitors, peptides, and other bulk drug intermediates. It also offers various active pharmaceutical ingredients, such as ivermectin, benfotiamine, dapoxetine, mupirocin, stanazolol, and more. The company serves various clients in the field of pharmaceuticals and nutraceuticals, including private, institutional, commercial, and corporate customers.
Jigs Chemical was established in 1998 and is based in India with global offices in the USA, UK, Canada, and Australia. Jigs Chemical is a manufacturer, distributor, and marketing & sales provider for organizations in India, specializing in chemicals and active pharmaceutical ingredients for pharmaceutical, agriculture, ceramics, metal treatment, and other industries. Jigs Chemical helps facilitate international customers to obtain chemicals from India, providing import and export assistance. Jigs Chemical’s product catalog includes over 40000 active pharmaceutical ingredients, commonly called APIs, their respective intermediates, and other chemicals.
Foodchem was founded in 2006 in Shanghai, China. The company is ISO 9001 certified and is a producer, distributor, R&D provider, and marketer of specialty and standard food additives and ingredients to pharmaceutical, cosmetic, nutrition, and chemical industries around the world through distributors and self-managed warehouses. The company operates through four product segments: Food Ingredients, Feed Additives, Industrial Chemicals, and Active Pharmaceutical Ingredients. Certain categories include Kosher and Halal-certified products and products meeting other dietary restrictions.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Merck |
100.0%
|
Derivation Method
The ranking is calculated based on the click share within the glucuronolactone page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
China
|
5 | 62.5% |
|
India
|
2 | 25.0% |
|
Japan
|
1 | 12.5% |
