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This section provides an overview for glycyrrhizic acids as well as their applications and principles. Also, please take a look at the list of 10 glycyrrhizic acid manufacturers and their company rankings.
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Okayama University Graduate School, Ph.D. (Agriculture). After working as a specially appointed Assistant Professor at Tokyo Medical and Dental University, a fluid researcher at the Okayama Prefectural Institute of Biological Sciences, and a special researcher (JSPS PD) at the Japan Society for the Promotion of Japan Science, he became independent as a freelancer.
Specializes in natural product chemistry, protein engineering, fermentation engineering, and instrumental analysis of chemicals (especially mass spectrometry chemistry).
Thesis: https://pubmed.ncbi.nlm.nih.gov/?term=HIROKAZU+USUKI
linkedin: https://www.linkedin.com/in/%E5%8D%9A%E4%B8%80-%E8%87%BC%E6%9C%A8-b83827228/
Glycyrrhizic acid is a triterpene glycoside consisting of two molecules of glucuronic acid attached to glycyrrhetinic acid.
It is also called glycyrrhizin. It is known to be contained in licorice, a leguminous plant, and is used in many Chinese medicines.
Glycyrrhizic acid has a number of uses. Glycyrrhizic acid has been reported to have physiological activities such as detoxification, anti-inflammatory, anti-allergic, and antitussive effects. Because of these characteristics, it is widely used as a food additive and in pharmaceuticals.
Glycyrrhizic acids are a constituent of licorice and are found in many Chinese herbal formulas. Dried licorice containing 2.0% or more of glycyrrhizic acids is used as a drug, and the Japanese Pharmacopoeia lists it as a crude drug in the form of a powder, extract, crude extract, or scorched licorice.
In addition, the following are Chinese herbal formulas that contain licorice and glycyrrhizic acids. Each of these requires glycyrrhizic acids for quality testing.
In addition, it is also contained in gargle medicine, lozenges for throat inflammation, topical analgesics, skin softeners, rhinitis medicine, nasal drops, eye drops, and gastrointestinal medicines.
The following substances are listed in the quasi-drug ingredient standards and can be used in quasi-drugs.
These are used in medicated soaps, shampoos, and sunscreens, and are believed to be effective against rough skin.
In the official list of food additives, there are three substances listed as containing glycyrrhizic acid: Glycyrrhizic Acids Extract, Disodium Glycyrrhizate, and Enzyme-Degraded Glycyrrhizic Acids. These are all used as sweeteners.
Licorice extract, which contains glycyrrhizic acids, is used as a natural sweetener because of its unique sweetness. Its sweetness is estimated to be 50 to 200 times that of sugar, and it is particularly effective in relieving saltiness. There are standards for its use as a food additive, and it is only allowed to be used in soy sauce and miso.
Glycyrrhizic acids are on the list of active ingredients in so-called medicated cosmetics. Cosmetics containing glycyrrhizic acids are treated as so-called medicated cosmetics.
1. Structure
2. Molecular Formula: C42h62o16
3. Molecular Weight: 822.94
4. INCI Name: Glycyrrhizic Acid
5. Melting Point: 220°C (Decomposition)
6. CAS: 1405-86-3
Glycyrrhizic acids actions are varied and mainly include the following:
Pseudohypoaldosteronism is a very rare disorder in frequency. However, it can cause weakness, numbness, tightness, and stiffness in the limbs, as well as a feeling of weakness, limpness, and muscle pain. Licorice is found in many Chinese herbal preparations and should be used with caution when concomitant medications are used.
When used in quasi-drugs and cosmetics, the following maximum limits are set in the list of additives for quasi-drugs as the total of glycyrrhizic acids and its salts and glycyrrhizic acids and its derivatives.
As hair dyes and permanent waving agents, glycyrrhizic acid, trisodium glycyrrhizate, dicaryl glycyrrhizate, monoammonium glycyrrhizate, beta-glycyrrhizic acid, glyceryl glycyrrhizate, stearyl glycyrrhizate, glycyrrhizinyl stearate, and glycyrrhizic acid and glycyrrhizic acid are used as hair dye and permanent wave agents. are converted to glycyrrhizic acids and glycyrrhetinic acids, and the total of glycyrrhizic acids and glycyrrhetinic acids is defined as 0.8%.
*Including some distributors, etc.
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Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
Biotech, launched in 2018 in Shaanxi province, China, is a manufacturer of plant-based natural extracts used in dietary supplements, food and beverage, health formulation, and health food industries. The company makes Fructus psoraleae extract - psoralen, Tribulus terrestris extract - saponins, Eucommia ulmoides male flower extract, Rhizoma drynariae extract, and leaf of broadleaf holly extract which are in compliance with Halal, ISO 9001, FDA, and GMP standards. Besides that, the company also manufactures custom plant-based products according to the client's needs.
Alps Pharmaceutical Ind. Co. Ltd., established in 1947 and headquartered in Hida-shi, Japan, functions as a global pharmaceutical product manufacturer. Its product line comprises of active pharmaceutical ingredients (APIs), veterinary APIs, food additives, and feed additives. The company adopts a strategic warehousing approach, maintaining the Okamae warehouse with an extensive capacity of 8,000 tons for both products and raw materials. This robust supply chain strategy allows them to effectively hedge against risks related to weather-induced crop failures, market price fluctuations, and procurement challenges.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Tokiwa Phytochemical Co. Ltd., founded in 1949, is a Japanese manufacturer headquartered in Sakura, Chiba, engaging in the phytochemistry sector. The company provides supplement ingredients from various plants, such as black currant, and food additives, like matcha and yuzu. It also produces pharmaceutical and supplement ingredients using Good Manufacturing Practices (GMP) to ensure high product quality. It manufactures plant-based cosmetic ingredients, such as ashwagandha leaf and green tea extracts, and research reagents. The company supplies these plant compound products to over 2,000 industries, serving domestic and global customers.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
AdooQ BioScience, founded in 2006 and headquartered in Irvine, California, is a supplier specializing in purity inhibitors, chemical probes and reference compounds. The company's product portfolio includes inhibitors for signaling pathways, epigenetics, apoptosis, stem cells, and proteins. These products serve as tools for researchers in academia as well as the biotechnology and pharmaceutical industries, facilitating the execution of experiments, exploration of diseases, and the potential development of treatments and therapies. The company has established over 25 distributors in 30 different countries, along with service networks spanning five continents, thereby ensuring a worldwide reach.
BioCrick Co., Ltd is located in Chengdu Tianfu Life Science Park in Sichuan Province, China. The company creates a natural product library which provides small molecular compounds with potential biological and pharmacological activities for pharmaceutical, agricultural, and biotechnology companies worldwide. The company’s database includes more than 8,000 compounds collected from natural sources such as as medicinal plants, herbs, fungus, and microbes. The company also a provider of peptides and lab reagents for biological research, carrying a product line in apoptosis, epigenetic, and cancer biology.
Arshine Pharmaceutical Co., Limited, established in 2007 in Ningxiang, Hunan province, is a distributor of raw materials such as sweeteners, preservatives, thickeners, flavors, and nutrition supplements. It distributes instant dry yeast, lutein powder marigold extract, jelly powder, and Arabic Gum CAS 9000-01-5 that serve pharmaceutical, nutrition and supplement, and health industries. It has organized events such as Vietstock Expo and Forum 2020, CPHI Worldwide Europe, F1 Asia 2020, CPHI SouthEast Asia 2020, and CPHI 2020.
Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
3 | 50.0% |
|
China
|
2 | 33.3% |
|
United States of America
|
1 | 16.7% |
