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This section provides an overview for crotonaldehyde as well as their applications and principles. Also, please take a look at the list of 12 crotonaldehyde manufacturers and their company rankings. Here are the top-ranked crotonaldehyde companies as of December, 2024: 1.Actylis, 2.KANTO CHEMICAL CO.,INC., 3.TRInternational, Inc..
Table of Contents
Crotonaldehyde is an organic compound that is classified as an unsaturated aldehyde.
Its molecular formula is C4H6O, and it has one double bond in the molecule. There are two types of geometric isomers, cis and trans, but the trans form is often referred to without any special mention.
The CAS registration numbers are 123-73-9 (trans), 15798-64-8 (cis), and 4170-30-3 (mixture), and the IUPAC nomenclature names are
"(E)-2-butenal" and "(Z)-2-butenal" for the trans and cis forms, respectively.
Other names such as "propylenaldehyde," "methyl propenal," and "β-methylacrolein" may also be used.
The main uses of crotonaldehyde are as a raw material for synthesizing organic compounds, such as butanol, butyl alcohol, crotonic acid, and sorbic acid. These compounds are used in various industrial products.
For example, butanol, which is synthesized using crotonaldehyde, is widely used in color paints, brake fluid, and fuels.
Crotonaldehyde is also used as a raw material for pharmaceuticals and agrochemicals due to its high synthetic value.
It is also used as a raw material for organic synthesis in research and development.
As mentioned above, there are two types of geometric isomers of crotonaldehyde: cis- and trans-forms. The trans form, which is mainly used, has a melting point of -76.5°C, a boiling point of 104.0°C, and a density of 0.853 g/cm3 (20°C).
The cis form has a melting point of -69°C (-69°F), but other physical properties information is less clear due to its limited use. It exists in liquid form at room temperature and is colorless and transparent.
It is characterized by a pale yellow color and pungent odor when exposed to light or air.
As mentioned above, there are two geometric isomers of crotonaldehyde, but the trans form is mainly used. Therefore, most of the products sold are trans isomers.
The trans isomer is mainly sold as a reagent product for research and development of organic synthesis, and is available in easy-to-handle laboratory volumes such as 25mL and 500mL. Acetonitrile, water, and methanol solutions also exist as products.
On the other hand, cis/trans mixtures can be purchased as pharmaceutical and agrochemical raw materials for industrial use. This product is available in tanker trucks, drums, oil cans, and other large cargoes for factory applications.
Crotonaldehyde is synthesized mainly by condensation of acetaldehyde. It can also be obtained by heating aldol with a mineral acid and distilling the reactants.
As for the reactivity of crotonaldehyde, it has an aldehyde group, which makes it easy to polymerize. In addition, when left in the air, it is gradually oxidized by oxygen in the air to crotonic acid.
Crotonaldehyde is a flammable substance with a low flash point of 13℃.
In addition, the vapor has a strong pungent odor, is tearing, and is known to be toxic.
When handling these substances, care must be taken, including the use of goggles.
*Including some distributors, etc.
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TRInternational Inc., founded in 1994 and headquartered in Edmonds, Washington, is a supplier of ingredients, raw materials, and services in North America. Its diversified product portfolio includes chemicals, rubber, and paints used in industries like metalworking, water treatment, and industrial cleaning. It has over 20 stocking and import points across the United States and offers additional services like custom manufacturing, contract packaging, and proprietary formulation. The company is SBA, WOSB, and LGBTBE certified, and in 2018, it was ranked number 70 in the Top 100 Chemical Distributors in North America.
Actylis is based in Port Washington, New York, USA, and is an ISO 13485-certified custom manufacturer of chemical compounds that was established in 1978 as a subsidiary of Aceto. The company mainly produces specialty chemical products for the pharmaceutical, biopharm, and agriscience sectors. These chemical products include cell culture ingredients, active pharmaceutical ingredients (APIs), and buffering salts. It also offers excipients, adenosine for cosmetic ingredients, and vitamins for nutritional supplements. The company operates internationally, with manufacturing facilities in Germany, the United Kingdom, and India. Some of its notable clients include Novartis, Nestlé, and Estée Lauder.
Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
ALPHA CHEMICA, established in 1985, is an Indian manufacturer and supplier of laboratory reagents and fine chemicals, headquartered in Mumbai, Maharashtra. Their wide range of products includes high-performance liquid chromatography (HPLC), analytical reagent/guaranteed reagent (AR/GR), laboratory reagents (LRs), and fine chemicals, catering to life science and other specialty research. During the COVID-19 pandemic and its aftermath, ALPHA CHEMICA offered BactGO, a disinfectant solution with stabilized hydrogen peroxide using silver-based chemistry, and BaVi-X, a 75% alcohol-based hand sanitizer.
SimSon Pharma Limited, established in 2011 and headquartered in Mumbai, India, is a manufacturer and supplier of pharmaceutical reference materials. Their product range includes drug working standards, drug impurity standards, drug metabolites, and stable isotope labeled compounds. These provide a basis for comparison and validation, enabling pharmaceutical companies to produce safe and effective medications. The company's offerings serve specific purposes, such as calibrating analytical instruments and ensuring precise analytical results, identifying and quantifying impurities in drugs, understanding drug metabolism, and developing new drug therapies.
GODAVARI BIOREFINERIES LTD. started in 2006 in Maharashtra, India, is a manufacturer of ethanol and ethanol-based products for consumer electronics, food preservation, adhesives and lubricants, pharmaceuticals, and textile industries. The company’s product portfolio comprises pharmaceutical-grade ethanol, branded sugar, biobased acetic acid, and hand sanitizers. It has received awards such as the FKCCI Export Award, India Green Energy, Silver Medal for Distillery in Karnataka, Combined Heat and Power Plant Boiler 2021, and Ensvosafe EHS Excellence.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
National Analytical Corporation (NAC) is located in Mumbai, India. NAC was founded in 2009 as a distributor of laboratory grade chemicals used in numerous industries. NAC’s chemical offerings include biochemical & reagents such s Prunetin and 1,2-dipalmitoly-rac-glycerol, analytical grade chemicals such as chicoric acid and Vitamin E solutions, laboratory chemicals such as formic acid and nitric acid, gas chromatography chemicals such as Aalborg mass flowmeter battery kits and DEX 225, reference standard chemicals such as Palladium in HNO3, oral solid dosage forms, such as cellulosic and protect film coating systems, parenteral dosage forms, beverage & nutrition, and coating chemicals.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Actylis |
13.5%
|
| 2 | KANTO CHEMICAL CO.,INC. |
13.0%
|
| 3 | TRInternational, Inc. |
11.4%
|
| 4 | Alpha Chemica |
10.8%
|
| 5 | Parchem |
9.2%
|
| 6 | Central Drug House |
8.1%
|
| 7 | GODAVARI BIOREFINERIES LTD. |
7.6%
|
| 8 | nacalai |
7.6%
|
| 9 | Ashok Chem Pharma International |
5.9%
|
| 10 | SimSon Pharma Limited |
5.9%
|
Derivation Method
The ranking is calculated based on the click share within the crotonaldehyde page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
5 | 50.0% |
|
United States of America
|
3 | 30.0% |
|
Japan
|
2 | 20.0% |
