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This section provides an overview for coumarin as well as their applications and principles. Also, please take a look at the list of 7 coumarin manufacturers and their company rankings. Here are the top-ranked coumarin companies as of December, 2024: 1.Junsei Chemical Co.,Ltd., 2.Merck, 3.KANTO CHEMICAL CO.,INC..
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Okayama University Graduate School, Ph.D. (Agriculture). After working as a specially appointed Assistant Professor at Tokyo Medical and Dental University, a fluid researcher at the Okayama Prefectural Institute of Biological Sciences, and a special researcher (JSPS PD) at the Japan Society for the Promotion of Japan Science, he became independent as a freelancer.
Specializes in natural product chemistry, protein engineering, fermentation engineering, and instrumental analysis of chemicals (especially mass spectrometry chemistry).
Thesis: https://pubmed.ncbi.nlm.nih.gov/?term=HIROKAZU+USUKI
linkedin: https://www.linkedin.com/in/%E5%8D%9A%E4%B8%80-%E8%87%BC%E6%9C%A8-b83827228/
Coumarin is an aromatic compound with a lactone (cyclic ester) structure.
It is stable in a solid state at room temperature, but is soluble in alcohol, ether, chloroform, and volatile oils, so it is often used in a dissolved state. This compound is found in cherry leaves, cinnamon, and plants of the tangerine and legume families. Its characteristic feature is its aroma, and it is also a component of the sweet aroma of sakura mochi (cherry blossom cakes).
It also has antioxidant, antibacterial, and anti-blood coagulation effects, and is believed to be effective in preventing swelling and aging.
Coumarin is abundantly contained in plants of the family Ceraceae, tangerine family, and leguminous family, and exists as a glycoside in plant organisms. Glycoside here refers to the presence of coumarin bound to sugars. Interestingly, coumarin as a glycoside does not have a specific aroma. The sweet aroma characteristic of sakura-mochi, as described above, is not due to the coumarin glycoside, but to the coumarin resulting from its hydrolysis.
C9H6O2
146.14
As shown above.
72°C
Easily soluble in diethyl ether, chloroform, pyridine, soluble in ethanol
Emits yellowish green fluorescence when irradiated with ultraviolet light.
It is synthesized from salicylaldehyde, acetic anhydride, and sodium acetate by the Parkin reaction.
Coumarin is one of the components of the so-called "cinnamon aroma," from which the sweet aroma of sakura-mochi is derived. This aroma is also reported to have a relaxing effect. Because of these characteristics, it is used as an ingredient in air fresheners and perfumes.
Coumarin is reported to improve blood flow and is thought to be effective in preventing swelling. In addition, its antioxidant properties help to remove active oxygen in the body. Because of these characteristics, coumarin is also expected to have an anti-aging function. On the other hand, it can cause liver damage if consumed in large quantities. Therefore, its use in the food industry is approved only as a component of flavorings and as a food additive for flavoring.
Some compounds with coumarin skeleton have blood coagulation inhibitory activity. A typical example is warfarin. This compound is a biologically active substance synthesized from dicoumarol, a metabolite of coumarin, as a lead compound, and is currently used as a blood coagulation inhibitor and rodenticide.
In some countries, coumarin is added to kerosene and fuel oil. The yellowish-green fluorescence of commercially available kerosene when irradiated with a black light is due to this coumarin as an additive, and is not a property of the kerosene itself. This use of coumarin is a good example of utilizing the two chemical properties of coumarin, its high fat-solubility and fluorescence.
*Including some distributors, etc.
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ChemUniverse, Inc. is a privately owned and operated specialty chemical provider that was founded in 2019.They are headquartered in Des Plaines, Illinois. They sell a wide range of chemicals, including amyl benzoate, naphthalene, pyridine, anethole, isoamyl benzoate, and many others which have different purposes. For instance, Amyl benzoate is a flavoring ingredient found in foods and perfumes while Naphthalene is a moth repellent and a component of various industrial solvents. They offer their services to customers looking for specialized or unique products and offer custom synthesis services to produce items that aren't already in their inventory.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Pell Wall Ltd. is a manufacturer, supplier, and distributor of fragrance and aroma chemicals based in the UK, established in 2011. The company primarily produces and distributes fragrance chemicals, essential in creating scents and fragrances for various consumer products, including perfumes, colognes, candles, lotions, and more. The company offers a diverse portfolio of fragrance ingredients that perfumers and product developers use to craft unique and appealing scents. The company also provides services for custom fragrance development, allowing clients to work with tailor-made fragrances that align with specific brand identities.
BioCrick Co., Ltd is located in Chengdu Tianfu Life Science Park in Sichuan Province, China. The company creates a natural product library which provides small molecular compounds with potential biological and pharmacological activities for pharmaceutical, agricultural, and biotechnology companies worldwide. The company’s database includes more than 8,000 compounds collected from natural sources such as as medicinal plants, herbs, fungus, and microbes. The company also a provider of peptides and lab reagents for biological research, carrying a product line in apoptosis, epigenetic, and cancer biology.
Ernesto Ventós S.A. is a company that was established in 1916 in Sant Just Desvern, Spain, specializing in distributing aroma compounds and essential oils to the fragrance and flavoring industries. Ventós is a company that has established solid commercial partnerships with significant raw material producers. As a result, they have become a distinguished agent or distributor of goods for these producers. The company has a wide range of over three thousand products, allowing them to offer efficient just-in-time service to their clients.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Junsei Chemical Co.,Ltd. |
25.0%
|
| 2 | Merck |
25.0%
|
| 3 | KANTO CHEMICAL CO.,INC. |
21.4%
|
| 4 | Pell Wall Ltd. |
10.7%
|
| 5 | Ernesto Ventós S.A. |
10.7%
|
| 6 | ChemUniverse, Inc. |
7.1%
|
Derivation Method
The ranking is calculated based on the click share within the coumarin page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
2 | 40.0% |
|
United States of America
|
1 | 20.0% |
|
United Kingdom
|
1 | 20.0% |
|
Spain
|
1 | 20.0% |
