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This section provides an overview for isoleucine as well as their applications and principles. Also, please take a look at the list of 14 isoleucine manufacturers and their company rankings. Here are the top-ranked isoleucine companies as of December, 2024: 1.Xintai Jiahe Biotech Co., Ltd, 2.KANTO CHEMICAL CO.,INC..
Table of Contents
Isoleucine is an organic compound with the chemical formula C6H13NO2.
It is abbreviated as Ile (three letters) or I (one letter). It has a structure with a sec-butyl group on the side chain, and is classified as one of the branched-chain amino acids and a hydrophobic amino acid, and the L-body is used in most cases.
It has a molecular weight of 131.17, a melting point of 288°C (decomposition), and is a white crystal or crystalline powder at room temperature. It is odorless or has a slight odor, pH is 5.5-7.0 (1%, 20℃), and solubility in water is 4.02g/100g (20℃). It is insoluble in ethanol and insoluble in diethyl ether.
Physiologically, isoleucine is classified as a type of essential amino acid that cannot be synthesized in the human body. Therefore, it is a substance that must normally be ingested from food and other sources. Major uses include pharmaceutical raw materials (e.g., infusions), culture media, and as an additive in foods and beverages. As a food additive, it is used to add flavor.
BCAAs are sometimes combined with valine and leucine to form BCAAs in supplements for muscle building. In synthetic chemistry, isoleucine is used in formulation research, amino acid research, and as an N-Fmoc protector in peptide synthesis.
Isoleucine has four isomers: L-isoleucine, D-isoleucine, L-allo-isoleucine, and D-allo-isoleucine. Of these, L-isoleucine is the one used in nature, including in vivo. Synthetically, it is synthesized by a multi-step reaction using 2-bromobutane and diethyl malonate as starting materials.
Isoleucine is not synthesized in the human body, but is biosynthesized in plants and microorganisms. 2-oxobutanoic acid is synthesized by various enzymes, and the specific synthetic pathways are as follows
Isoleucine is one of the essential amino acids in the human body. It helps strengthen muscles and relieve fatigue. For this reason, it is also called BCAA, along with the essential amino acids valine and leucine. It has also been shown to suppress elevated blood sugar levels, dilate blood vessels, and enhance liver function.
There are two main types of isoleucine available on the market today: industrial products and R&D products. Industrial products are often used in food additives and are generally offered in large quantities, such as 1 kg, 25 kg, and 50 kg. The main type of isoleucine sold is L isoleucine.
For research and development use, in addition to L isoleucine, racemic isoleucine is also sold as "DL-isoleucine. 5g, 10g, 25g, 50g, 100g, 500g, etc." These are sold in small volumes that are easy to handle in the laboratory. Basically, these chemicals can be stored at room temperature. Also, for amino acid research and peptide synthesis, N-Fmoc protectors and other amino acid terminally protected products are available. These are basically reagents that are kept refrigerated or frozen.
Other products using isoleucine as an ingredient, such as supplements, are also widely available to the public.
*Including some distributors, etc.
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Kyowa Hakko Bio Co., Ltd. was established in 2008 and is based in Tokyo, Japan, as a manufacturer of pharmaceutical raw materials and ingredients. It specializes in manufacturing bulk pharmaceuticals like citicoline, L-glutathione, and L-ornithine aspartate. It also manufactures raw materials for infusions, dietary supplements, and cosmetics, such as amino acids, peptides, oligosaccharides, and nucleic acids. The company is a subsidiary of Kirin Holdings Company and has obtained ISO 22000:2018, ISO/TS 22002-1:2009, and FSSC 22000 certifications. Its manufactured products are utilized in pharmaceuticals, nutritional supplements, industrial, and cosmetics sectors across Japan, China, the USA, Germany, and Italy.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Avanschem, established in 2012, a manufacturer of a wide range of products such as cyanuric acid, pegelatinized sarch, welan gum, and more, operating from a prime location of Gurgaon, Haryana, India. The company provides products developed from of top-notch ingredients and industrial chemicals, for lab and Industrial use. These products formulated using chemical compounds under controlled temperature and pressure conditions at their sophisticated laboratory. They specialize in formulations & contract manufacturing, dossiers services, sourcing services and others, with a worldwide distribution network.
VIVAN Life Sciences Pvt. Limited, launched in 2010 in Maharashtra, India, is a manufacturer of chemical synthesis and product development products for pharmaceutical companies, contract manufacturing firms, university research labs, and contract research organizations. The company's product catalog includes building blocks, customized research chemicals, stable isotope labeled compounds, organoborane amine complexes, and specialized chemical manufacturing. It also provides custom synthesis services (CSS), chemical contract research (CCR), and contract manufacturing services. The company is accredited by CRISIL MSE 2, ISO 17034: 2016, ISO IEC 17025: 2005.
Jigchem Universal is a manufacturer of active pharmaceutical ingredients (APIs) and chemicals that was established in 2002 in Maharashtra, India. The company produces compounds used for a wide range of applications such as medication, industrial processing, and personal care products. Its products include inorganic solvents for surface treatment of various materials, APIs for human or veterinary use, and biocides for water treatment processes. The company serves clients in the pharmaceutical manufacturing, laboratory research, and metal fabrication sectors.
Yichang Sanxia Proudin Biopharmaceutical Co., Ltd., founded in China in 1974, is a manufacturer of Amino Acid series raw materials. The company's product portfolio includes Pharmaceutical Grade Amino Acids, Amino Acids for Special Medical Food, Amino Acids for Medium, High-Purity Pharmaceutical Intermediate Amino Acid and Food Grade Amino Acids. Their products are used in industries such as Food and Beverage, Pharmaceutical and Biotechnology, Chemical and Petrochemical, Environmental Testing and healthcare.
Jinan Qinmu Fine Chemical Co., Ltd., established in 2008, is a Chinese manufacturer of chemical products, headquartered in Jinan, Shandong. The company offers organic and inorganic chemicals, including solvent chemicals, catalysts, and auxiliaries. Additionally, the company provides dye and pigment chemicals, pharmaceutical and synthetic intermediates, active pharmaceutical ingredients (APIs), and biochemical products. Customized intermediates are also available to meet the specific needs of original equipment manufacturers (OEMs). As an ISO 9001 and ISO 14001 certified company, Qinmu Fine Chemical Co., Ltd. serves a global customer base, including clients like Miwon Specialty Chemical Co., Ltd., Synthos S. A., and Gujarat Fluorochemicals Limited (GFL).
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Xintai Jiahe Biotech Co. Ltd. is a supplier of bioactive compounds and nutritional ingredients, headquartered in Shantou City, Guangdong Province. The company specializes in the research, development, production, and sales of amino acids, vitamins, pharmaceutical intermediates, nucleotides, and its derivatives. It offers a diverse range of products, including L-Serine, L-Phenylalanine, L-Acetic Acid Lysine, L-Leucine, and L-Tryptophan, which are utilized in various industries such as nutrition, food additives, cosmetics, and pharmaceuticals. The company upholds quality standards with certifications like ISO, FSSC22000, HACCP, KOSHER, HALAL, and BRC.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
Glentham Life Sciences is based in Corsham, United Kingdom. Glentham Life Sciences is a leading supplier of fine chemicals, raw materials, reagents, and life science products. Glenthem also offers a number of services including custom packaging, call-off orders, and safety documentation. Glentham’s product offerings include chemicals such as amino acids, antibiotics, APIs, biochemicals, buffers, carbohydrates, chitin, chitosan, detergents, dyes, stains, enzymes, inorganic, peptide reagents, phytochemical, raw materials, solvents, steroids, and vitamins among others.
Foodchem was founded in 2006 in Shanghai, China. The company is ISO 9001 certified and is a producer, distributor, R&D provider, and marketer of specialty and standard food additives and ingredients to pharmaceutical, cosmetic, nutrition, and chemical industries around the world through distributors and self-managed warehouses. The company operates through four product segments: Food Ingredients, Feed Additives, Industrial Chemicals, and Active Pharmaceutical Ingredients. Certain categories include Kosher and Halal-certified products and products meeting other dietary restrictions.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Xintai Jiahe Biotech Co., Ltd |
50.0%
|
| 2 | KANTO CHEMICAL CO.,INC. |
50.0%
|
Derivation Method
The ranking is calculated based on the click share within the isoleucine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
5 | 38.5% |
|
China
|
4 | 30.8% |
|
Japan
|
3 | 23.1% |
|
United Kingdom
|
1 | 7.7% |
